Synthetic Hormones Found to Cause Breast Cancer, Again


Breast Cancer at White arrow

Synthetic Hormones Found to Cause Breast Cancer, Again

by Jeffrey Dach MD

A friend and colleague, Phyllis J. Bronson, Ph.D. (3) sent me an email about a new report that women’s hormones cause breast cancer.  This was published March 29 in the Journal of the National Cancer Institute.  Upon closer inspection, the report is a rehash of the old NIH study, the Women’s Health Initiative, which was terminated early because Prempro, caused breast cancer and heart disease.(1,2)

This information was published originally in 2002 and again in 2011 in JAMA by the same authors. See my previous article which discussed this.  Above image: breast cancer in specimen radiograph courtesy of jeffrey dach md.

Prempro Causes Breast Cancer and Heart Disease

The NIH sponsored Women’s Health Initiative study was terminated early because Prempro, was found to cause breast cancer and heart disease.   Prempro contains Provera (medroxyprogesteone), and Premarin, estrogen from pregnant horses.   Provera is a synthetic chemically altered progesterone never found in nature or in the human body, and for years has been known to cause cancer and heart disease, much like other chemically altered hormones.  These chemically altered hormones are, in fact, monsters which should never have been approved for human consumption.

More Breast Cancer in the Prempro Users

Breast Cancer

Breast Cancer

Over 11 years of observation, the (Prempro) estrogen plus progestin users had 0.60% incidence of breast cancer, while the non-users had  0.42%.  This is roughly one and a half times more breast cancer in the Prempro users.

Left image: breast cancer in specimen radiograph with Homer needle in place, used to localize the lesion. Coutesy of Jeffrey Dach MD personal archives.

How Do We Know Provera (medroxyprogestroene) Caused the Increased Breast Cancer?

We know this because the NIH study included another group that was given Prempro minus the Provera.  These women had hysterectomies,  so did not need the progestin, Provera. They were given solely Premarin, the horse estrogen.  These Premarin treated women actually had reduced incidence of breast cancer compared to controls,  23% less, as matter of fact.

Medroxyprogresterone (MPA Mouse Model of Breast Cancer

It is simply astounding that the mainstream medical system will prescribe medroxyprogesterone (MPA) to women, even though this same drug is commonly used to induce breast cancer in animal models.(4)

How to Prevent Breast Cancer

1) Avoid Prempro- and all other synthetic hormone pills, xeno-estrogens, pesticides and chemicals that increase breast cancer rates.

2) Use Bio-Identical Hormones-these are naturally found in the human body and do not increase breast cancer rates or heart disease.

3) Use Iodine,  Vitamin D and Selenium supplementation.

Jeffrey Dach MD

Articles with related interest:

The Safety of Bioidentical Hormones

The Importance of BioIdentical Hormones

Links and References:

Estrogen Plus Progestin and Breast Cancer Incidence and Mortality in the Women’s Health Initiative Observational Study by Rowan T. Chlebowski,   JoAnn E. Manson,   published March 29 in the Journal of the National Cancer Institute.  Affiliation of authors: Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA (RTC); Brigham and Women’s Hospital, Harvard Medical School, Boston, MA (JEM); Fred Hutchinson Cancer Research Center, Seattle, WA (GLA, CC, AKA, PAN); University of Pittsburgh, Pittsburgh, PA (JAC); Stanford University, Stanford, CA (MLS); State University of New York, Stony Brook, NY (DSL); University of Tennessee Health Science Center, Memphis, TN (KCJ); University at Buffalo, Buffalo, NY (JWW); University of California at Davis, Sacramento, CA (LQ, SY).

Background In the Women’s Health Initiative (WHI) randomized trial, estrogen plus progestin increased both breast cancer incidence and mortality. In contrast, most observational studies associate estrogen plus progestin with favorable prognosis breast cancers. To address differences, a cohort of WHI observational study participants with characteristics similar to the WHI clinical trial was studied.

Methods We identified 41, 449 postmenopausal women with no prior hysterectomy and mammogram negative within 2 years who were either not hormone users (n = 25 328) or estrogen and progestin users (n = 16 121). Multivariable-adjusted Cox proportional hazard regression was used to calculate hazard ratios (HRs) with 95% confidence intervals (CI). All statistical tests were two-sided.

Results After a mean of 11.3 (SD = 3.1) years, with 2236 breast cancers, incidence was higher in estrogen plus progestin users than in nonusers (0.60% vs 0.42%, annualized rate, respectively; HR = 1.55, 95% CI = 1.41 to 1.70, P < .001). Women initiating hormone therapy closer to menopause had higher breast cancer risk with linear diminishing influence as time from menopause increased (P < .001). Survival after breast cancer, measured from diagnosis, was similar in combined hormone therapy users and nonusers (HR = 1.03, 95% CI = 0.79 to 1.35). On a population basis, there were somewhat more deaths from breast cancer, measured from cohort entry (HR = 1.32, 95% CI = 0.90 to 1.93, P = .15), and more all-cause deaths after breast cancer (HR = 1.65, 95% CI = 1.29 to 2.12, P < .001) in estrogen plus progestin users than in nonusers.

Conclusions Consistent with WHI randomized trial findings, estrogen plus progestin use is associated with increased breast cancer incidence. Because prognosis after diagnosis on combined hormone therapy is similar to that of nonusers, increased breast cancer mortality can be expected.

Hormone Therapy May Raise Risk of Aggressive Breast Cancers
Mar 29, 2013 | 4:13 PM ET | Rachael Rettner, MyHealthNewsDaily Staff Writer
Women who undergo hormone-replacement therapy (HRT) to treat symptoms of menopause are at increased risk of developing all categories of breast cancer, a new study has found.  In the study, postmenopausal women on hormone replacement therapy that included both estrogen and progestin were 1.5 times more likely to develop breast cancer over an 11-year period compared with women not on the hormones.  HRT increased the risk of breast cancers that have a low risk of recurrence, such as estrogen-receptor-positive cancers, as well as the risk of more aggressive breast cancers, such as triple-negative breast cancer.   The findings back up the results of a study published last year that suggested HRT increased the risk of all categories of breast cancer. Before that study, doctors thought that HRT only increased the risk of less-serious cancers, said study researcher Dr. Rowan Chlebowski, of the Los Angeles Biomedical Research Institute.   The new findings lead to more of a consensus on the link between HRT and breast cancer, and suggest doctors should exercise even more caution when prescribing the treatment, Chlebowski said.

The decision to start HRT should be made on a case-by-case basis, Chlebowski said. Women should speak with their doctors about the risks and benefits of the therapy. The benefits will be greater for those with more severe symptoms of menopause, Chlebowski said.  The National Institutes of Health has stated that if women decide to receive HRT, they should take the lowest dose for the shortest amount of time, and be re-evaluated every six months to see if they still need the treatment.  Recently, several doctors groups said that for women under age 60, or for those who reached menopause within the past 10 years, the benefits of HRT generally outweigh the risks.  The link between HRT use and an increased risk of breast cancer was first seen in 2002, when a large study on the effects of estrogen and progestin therapy was suspended because researchers found the treatment increased the risk of invasive breast cancer..   The new study analyzed information from 41,000 postmenopausal women ages 50 to 79, about half of whom were taking HRT (estrogen plus progestin) at some point in the study, and half who were not on the therapy.  During the study period, about 2,200 women were diagnosed with invasive breast cancer. Among those who took HRT, 0.6 percent developed breast cancer each year, compared with 0.42 percent for those who weren’t on HRT.  Women’s survival after a breast-cancer diagnosis was about the same for both groups. However, because more women who took HRT developed breast cancer, the findings suggest that the use of HRT may increase deaths from breast cancer in the population as a whole, the researchers said.  The findings support what doctors have already been doing to recognize the risk of breast cancer with HRT, said Dr. Erin Olson, an oncologist at Ohio State’ s James Cancer Hospital who was not involved in the study.  In an editorial accompanying the study, Catherine Schairer and Louise Brinton, of the National Cancer Institute, said that the new study does not provide definitive evidence that HRT increases the risk of both low-risk and aggressive cancers. To answer this question, more studies will need to take into account the length of time the women are on the therapy.  The study was published in the March 29 issue of the Journal of the National Cancer Institute.

3) Phyllis J. Bronson, Ph.D.
Biochemical Consulting Company
Biochemical Research Foundation, Aspen
University of Denver: Department of Chemistry/Biochemistry
International Society for Orthomolecular Medicine

4) Lanari, Claudia, et al. “The MPA mouse breast cancer model: evidence for a role of progesterone receptors in breast cancer.” Endocrine-related cancer 16.2 (2009): 333-350.  The MPA mouse breast cancer model Lanari Claudia 2009
More than 60% of all breast neoplasias are ductal carcinomas expressing estrogen (ER) and progesterone receptors (PR). By contrast, most of the spontaneous, chemically or mouse mammary tumor virus induced tumors, as well as tumors arising in genetically modified mice do not express hormone receptors. We developed a model of breast cancer in which the administration of medroxyprogesterone acetate to BALB/c female mice induces mammary ductal carcinomas with a mean latency of 52 weeks and an incidence of about 80%. These tumors are hormone-dependent (HD), metastatic, express both ER and PR, and are maintained by syngeneic transplants. The model has been further refined to include mammary carcinomas that evolve through different stages of hormone dependence, as well as several hormone-responsive cell lines. In this review, we describe the main features of this tumor model, highlighting the role of PR as a trigger of key signaling pathways mediating tumor growth. In addition, we discuss the relevance of this model in comparison with other presently used breast cancer models pointing out its advantages and limitations and how, this model may be suitable to unravel key questions in breast cancer.
Jeffrey Dach MD
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Davie, Fl 33314

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Last updated on by Jeffrey Dach MD

Synthetic Hormones Found to Cause Breast Cancer, Again
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Synthetic Hormones Found to Cause Breast Cancer, Again
A friend and colleague, Phyllis J. Bronson, Ph.D. Sent me an email about a new report that women's hormones cause breast cancer.
Jeffrey Dach MD
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4 thoughts on “Synthetic Hormones Found to Cause Breast Cancer, Again

  1. Phyllis Bronson PhD
    Generally women age far less well without their hormones.
    As a biochemist who studies both molecular and clinical aspects of women’s mood chemistry, I see Jeffrey Dach as a rare physician who sees the truth about the molecules being prescribed. The darkest secret in women’s health is the lack of distinction between synthetic progestins- sometimes misleadingly called progesterone- in the medical literature , and real progesterone. Real progesterone is the critical molecule for producing calmness at all ages, very crucial for women with or without hysterectomy as there are progesterone receptors throughout the female body that greatly impact mood. While progesterone is a secondary molecule in importance to estrogen it is the missing link in these large randomized flawed studies such as WHI.

  2. It is simply amazing that the media never mentions natural progesterone as the safer alternative to the synthetic progestins

    Synthetic progestins are known to cause cancer and heart disease. They are monsters that should be avoided.

    Natural human progesterone does not cause breast cancer nor heart diease and is preferable.

    Thanks for the comment , Phyllis

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