Remission from Crohns Disease with Low Dose Naltrexone

Remission from Crohns Disease with Low Dose NaltrexoneA Case of Remission from Crohn’s Disease with Low Dose Naltrexone LDN by Jeffrey Dach MD

Tom came into my office about 6 months ago.  He is a 32 year old male with a long history of inflammatory bowel disease.  He has been evaluated and treated by many gasteroenterologists over the years, and was told he has Crohn’s Disease, and will never fully recover.

Left Image: Crohn’s with typical ulceration of distal ileum on barium xray courtesy of jeffrey dach md.

Tom had seen my previous article on Low Dose Naltrexone, and he was interested in using it for his Crohn’s Disease.   None of his other doctors would give it to him.  I started him on the drug immediately.  LDN is safe with virtually no adverse side effects, and has been shown effective for Crohn’s Disease in a 2007 report, “Low-dose naltrexone therapy improves active Crohn’s disease” by Jill Smith MD at  Penn State University.(1-2) A second larger study was reported in 2011.(2)

Crohn’s Disease is a chronic inflammatory condition of the small bowel, and complete recovery is very rare. The following is an email from Tom describing his experience after 6 months of treatment with LDN:

Thank you for helping me get rid of symptoms of one of the most
problematic and debilitating diseases.  For more than 10 years I had  been struggling with Crohn’s disease and fighting a losing battle.  For a lot of people, Crohn’s disease doesn’t respond well to traditional methods of treatment.

The anti-inflammatory drugs I was taking before I saw Dr. Dach had very little effect and the prednisone was such a destructive drug, I could only be on it for short periods of time.  I gained 85 pounds on my last round of prednisone and as soon as I came off, the bleeding and intestinal pain resumed and I started worrying about long car rides and being far from bathrooms.  This had a big impact on my personal and professional life.  I knew that if I ever wanted to get rid of the disease it would be with an unconventional treatment.

I first heard of LDN from doing a search on the internet and made an appointment with Dr. Dach.  I had exhausted every possible option before and felt like I had no where else to turn.  When I went to my appointment, Dr. Dach spent a lot of time with me and it felt very different than the “assembly line approach” that I was used to.

My first visit was in the summer of 2008 and I’ve been symptom-free ever since.  I could feel my body healing almost immediately after starting treatment.  For me, low-dose naltrexone has been a miracle drug.  I can now lead a normal life and do all kinds of things Crohn’s disease would have prevented me from doing, like sitting through a movie or taking a long car trip.  This has changed my life and I hope more people can benefit.

Regards, from Tom

———————————————————-

Other Uses for LDN:

LDN has been found beneficial in Ulcerative Colitis, Multiple Sclerosis, Fibromyalgia/Chronic Pain syndromes, Autonomic Dysfunction/POTS,  Sarcoidoisis, Scleroderma, and most other autoimmune disease.(3-11)

Chronic Pain/Fibromyalgia: LDN has been found useful see my previous article, LDN Part Four.

Articles With Related Content:

Low Dose Naltrexone LDN  Part One
Low Dose Naltrexone LDN Part 2
LDN for Neuropathic Pain PArt Four

Jeffrey Dach MD

https://www.jeffreydachmd.com/
www.drdach.com
www.naturalmedicine101.com
www.truemedmd.com
Disclaimer:
http://www.drdach.com/wst_page20.html
The reader is advised to discuss the comments on these pages with
his/her personal physicians and to only act upon the advice of his/her personal physician. Also note that concerning an answer which appears as an electronically posted question, I am NOT creating a physician — patient relationship. Although identities will remain confidential as much as possible, as I can not control the media, I can not take responsibility for any breaches of confidentiality that may occur.

Link to this article:  http://wp.me/P3gFbV-zp

(c) 2009-2016 Jeffrey Dach MD All Rights Reserved
This article may be reproduced on the internet without permission, provided there is a link to this page and proper credit is given.

References:

1) Smith, Jill P., et al. “Low-dose naltrexone therapy improves active Crohn’s disease.” The American journal of gastroenterology 102.4 (2007): 820.  Low-dose naltrexone therapy improves active Crohn’s disease Smith Jill Amer j gastroenterology 2007

Endogenous opioids and opioid antagonists have been shown to play a role in healing and repair of tissues. In an open-labeled pilot prospective trial, the safety and efficacy of low-dose naltrexone (LDN), an opioid antagonist, were tested in patients with active Crohn’s disease.
METHODS: Eligible subjects with histologically and endoscopically confirmed active Crohn’s disease activity index (CDAI) score of 220-450 were enrolled in a study using 4.5 mg naltrexone/day. Infliximab was not allowed for a minimum of 8 wk prior to study initiation. Other therapy for Crohn’s disease that was at a stable dose for 4 wk prior to enrollment was continued at the same doses. Patients completed the inflammatory bowel disease questionnaire (IBDQ) and the short-form (SF-36) quality of life surveys and CDAI scores were assessed pretreatment, every 4 wk on therapy and 4 wk after completion of the study drug. Drug was administered by mouth each evening for a 12-wk period.
RESULTS: Seventeen patients with a mean CDAI score of 356 +/- 27 were enrolled. CDAI scores decreased significantly (P= 0.01) with LDN, and remained lower than baseline 4 wk after completing therapy. Eighty-nine percent of patients exhibited a response to therapy and 67% achieved a remission (P < 0.001). Improvement was recorded in both quality of life surveys with LDN compared with baseline. No laboratory abnormalities were noted. The most common side effect was sleep disturbances, occurring in seven patients.
CONCLUSIONS: LDN therapy appears effective and safe in subjects with active Crohn’s disease. Further studies are needed to explore the use of this compound.

2) Smith, Jill P., et al. “Therapy with the opioid antagonist naltrexone promotes mucosal healing in active Crohn’s disease: a randomized placebo-controlled trial.” Digestive diseases and sciences 56.7 (2011): 2088-2097.

3) Matters, Gail L., et al. “The opioid antagonist naltrexone improves murine inflammatory bowel disease.” Journal of immunotoxicology 5.2 (2008): 179-187.

Inflammatory bowel disease (IBD) is a condition of the intestine with significant morbidity. Although hereditary, environmental, immunologic, and bacterial factors have been implicated, the etiology of IBD remains unknown. Since opioid peptides modulate inflammatory cytokine production and opioid antagonists promote tissue growth and repair, we hypothesized the opioid antagonist naltrexone could reduce inflammation of the bowel. Using a chemically-induced mouse model of IBD, C57BL/6J mice received either untreated drinking water or water containing 2% dextran sulfate sodium (DSS) in two parallel regimens modeling moderate and severe colitis. After colitis was established, animals in the moderate colitis study were administered either saline (control) or naltrexone (NTX; 8 or 400 microg/kg) daily, while those in the severe colitis study received 0.1 or 10 mg/kg NTX. DSS-treated animals had significant weight loss (p = 0.006) and higher disease activity index (DAI) scores (p < 0.001) compared to water controls. However, NTX treatment of mice with moderate colitis resulted in less weight loss, lower DAI scores, and less histologic evidence of inflammation compared to controls. Significantly, elevated levels of colonic RNA for pro-inflammatory cytokines interleukin (IL)-6 and IL-12 were also decreased toward normal with NTX. Similar to patients with severe and unresponsive disease, animals in the severe colitis study did not significantly respond to treatment. Thus, NTX therapy reverses physical symptoms, histologic evidence, and molecular markers of inflammation in moderate colitis. The mechanism by which NTX acts to reverse colitis is related in part to the decreased expression of pro-inflammatory cytokines.

4)  Lie, Mitchell RKL, et al. “Low dose Naltrexone for induction of remission in inflammatory bowel disease patients.” Journal of Translational Medicine 16 (2018).
Low dose Naltrexone induced clinical improvement in 74.5%, and remission in 25.5% of patients. Naltrexone improved wound healing and reduced ER stress induced by Tunicamycin, lipopolysaccharide or bacteria in epithelial barriers. Inflamed mucosa from IBD patients showed high ER stress levels, which was reduced in patients treated with LDN. Cytokine levels in neither epithelial cells nor serum from IBD patients were affected.
Naltrexone directly improves epithelial barrier function by improving wound healing and reducing mucosal ER stress levels. Low dose Naltrexone treatment is effective and safe, and could be considered for the treatment of therapy refractory IBD patients.

5) Weinstock, Leonard B. “Naltrexone Therapy for Crohn’s Disease and Ulcerative Colitis.” Journal of clinical gastroenterology 48.8 (2014): 742. Naltrexone Therapy Crohns Disease Ulcerative Colitis Weinstock Leonard B J clin gastroenterology 2014

“Adjunctive therapy with low dose naltrexone appeared to be a safe and possibly effective therapy in ulcerative colitis”

=============== =

6) ALS – and LDN ALS Untangled No 8 Low dose naltrexone for ALS

Sarcoidosis

7) Weinstock, Leonard, Trisha L. Myers, and Anup Shetty. “Low-dose Naltrexone for the treatment of sarcoidosis.” Sarcoidosis vasculitis and diffuse lung disease 34.2 (2017): 184-187.  Low-dose Naltrexone for Sarcoidosis Weinstock Leonard Sarcoidosis vasculitis lung disease 2017

Systemic Sclerosis (Scleroderma)

8) Frech, Tracy, et al. “Low-dose naltrexone for pruritus in systemic sclerosis.” International journal of rheumatology 2011 (2011).

Fibromyalgia

9) Younger, Jarred, and Sean Mackey. “Fibromyalgia symptoms are reduced by low-dose naltrexone: a pilot study.” Pain medicine 10.4 (2009): 663-672.
Fibromyalgia is a chronic pain disorder that is characterized by diffuse musculoskeletal pain and sensitivity to mechanical stimulation. In this pilot clinical trial, we tested the effectiveness of low-dose naltrexone in treating the symptoms of fibromyalgia.
DESIGN:  Participants completed a single-blind, crossover trial with the following time line: baseline (2 weeks), placebo (2 weeks), drug (8 weeks), and washout (2 weeks).
PATIENTS: Ten women meeting criteria for fibromyalgia and not taking an opioid medication.
INTERVENTIONS:  Naltrexone, in addition to antagonizing opioid receptors on neurons, also inhibits microglia activity in the central nervous system. At low doses (4.5 mg), naltrexone may inhibit the activity of microglia and reverse central and peripheral inflammation.
OUTCOME MEASURES: Participants completed reports of symptom severity everyday, using a handheld computer. In addition, participants visited the lab every 2 weeks for tests of mechanical, heat, and cold pain sensitivity.
RESULTS: Low-dose naltrexone reduced fibromyalgia symptoms in the entire cohort, with a greater than 30% reduction of symptoms over placebo. In addition, laboratory visits showed that mechanical and heat pain thresholds were improved by the drug. Side effects (including insomnia and vivid dreams) were rare, and described as minor and transient. Baseline erythrocyte sedimentation rate predicted over 80% of the variance in drug response. Individuals with higher sedimentation rates (indicating general inflammatory processes) had the greatest reduction of symptoms in response to low-dose naltrexone.
CONCLUSIONS: We conclude that low-dose naltrexone may be an effective, highly tolerable, and inexpensive treatment for fibromyalgia.

10) Chopra, Pradeep, and Mark S. Cooper. “Treatment of complex regional pain syndrome (CRPS) using low dose naltrexone (LDN).” Journal of Neuroimmune Pharmacology 8.3 (2013): 470-476.
Complex Regional Pain Syndrome (CRPS) is a neuropathic pain syndrome, which involves glial activation and central sensitization in the central nervous system. Here, we describe positive outcomes of two CRPS patients, after they were treated with low-dose naltrexone (a glial attenuator), in combination with other CRPS therapies. Prominent CRPS symptoms remitted in these two patients, including dystonic spasms and fixed dystonia (respectively), following treatment with low-dose naltrexone (LDN). LDN, which is known to antagonize the Toll-like Receptor 4 pathway and attenuate activated microglia, was utilized in these patients after conventional CRPS pharmacotherapy failed to suppress their recalcitrant CRPS symptoms.

Dysautonomia POTS

11) Weinstock, Leonard B., et al. “Case Report: Successful treatment of postural orthostatic tachycardia and mast cell activation syndromes using naltrexone, immunoglobulin and antibiotic treatment.” BMJ case reports 2018 (2018). Successful treatment postural orthostatic tachycardia mast cell activation syndrome naltrexone immunoglobulin antibiotic Weinstock Leonard BMJ case reports 2018

Multiple Sclerosis, and others

12) Toljan, Karlo, and Bruce Vrooman. “Low-Dose Naltrexone (LDN)—Review of Therapeutic Utilization.” Medical Sciences 6.4 (2018): 82. Low Dose Naltrexone LDN Review of Therapeutic Utilization Toljan Karlo Bruce Vrooman Medical Sciences 2018

Gut Dysbiosis

 Dysbiotic gut microbiota causes transmissible Crohn’s disease-like ileitis independent of failure in antimicrobial defence. Gut doi:10.1136/gutjnl-2015-309333 by Dirk Haller, Chair of Nutrition and Immunology, ZIEL-Institute for Food and Health, Technische Universität München, ZIEL—Research Center for Nutrition and Food Sciences, Gregor-Mendel-Str.2, Freising-Weihenstephan 85350, German

We provide clear experimental evidence for the causal role of gut bacterial dysbiosis in the development of chronic ileal inflammation with subsequent failure of Paneth cell function.

Jeffrey Dach MD
7450 Griffin Road, Suite 190
Davie, Fl 33314
954-792-4663
www.jeffreydachmd.com
www.drdach.com
Heart Book by Jeffrey Dach
www.naturalmedicine101.com
www.bioidenticalhormones101.com
www.truemedmd.com

Click Here for: Dr Dach’s Online Store for Pure Encapsulations Supplements
Click Here for: Dr Dach’s Online Store for Nature’s Sunshine Supplements

Web Site and Discussion Board Links:

jdach1.typepad.com/blog/
disc.yourwebapps.com/Indices/244066.html
disc.yourwebapps.com/Indices/244067.html
http://sci.med.narkive.com/covV2Qo2/jeffrey-dach-book-announcment-natural-medicine-101

Disclaimer

The reader is advised to discuss the comments on these pages with his/her personal physicians and to only act upon the advice of his/her personal physician. Also note that concerning an answer which appears as an electronically posted question, I am NOT creating a physician — patient relationship. Although identities will remain confidential as much as possible, as I can not control the media, I can not take responsibility for any breaches of confidentiality that may occur.

Link to this article

Copyright (c) 2018 Jeffrey Dach MD All Rights Reserved. This article may be reproduced on the internet without permission, provided there is a link to this page and proper credit is given.

FAIR USE NOTICE: This site contains copyrighted material the use of which has not always been specifically authorized by the copyright owner. We are making such material available in our efforts to advance understanding of issues of significance. We believe this constitutes a ‘fair use’ of any such copyrighted material as provided for in section 107 of the US Copyright Law. In accordance with Title 17 U.S.C. Section 107, the material on this site is distributed without profit to those who have expressed a prior interest in receiving the included information for research and educational purposes.

Serving Areas of: Hollywood, Aventura, Miami, Fort Lauderdale, Pembroke Pines, Miramar, Davie, Coral Springs, Cooper City, Sunshine Ranches, Hallandale, Surfside, Miami Beach, Sunny Isles, Normandy Isles, Coral Gables, Hialeah, Golden Beach ,Kendall,sunrise, coral springs, parkland,pompano, boca raton, palm beach, weston, dania beach, tamarac, oakland park, boynton beach, delray,lake worth,wellington,plantation

Summary
Remission from Crohns Disease with Low Dose Naltrexone
Article Name
Remission from Crohns Disease with Low Dose Naltrexone
Description
Remission from Crohns Disease with Low Dose Naltrexone
Author
publisher
Jeffrey Dach MD
publisher logo

About Jeffrey Dach MD

Medical Director of TrueMedMD, a Clinic in Davie Florida specializing in Bioidentical Hormones and Natural thyroid. Office address 7450 Griffin Road Suite 190, Davie, Florida 33314 telephone 954-792-4663

One thought on “Remission from Crohns Disease with Low Dose Naltrexone

  1. Pingback: Low Dose Naltrexone Part Four - Jeffrey Dach MD

Leave a Reply