Cambridge Finds Major Flaw in mRNA Technology

Cambridge Finds Major Flaw in mRNA Technology

A new study (Dec 2023) by Tom Mulroney et al., at the University of Cambridge found that one third of 21 patients injected with mRNA vaccine had off-target immune responses. The cause of this was identified as the synthetic RNA, pseudo-uridine in the mRNA sequence. This synthetic RNA causes a ribosomal “slippage” and misreading of the mRNA code 10% of the time, producing proteins contains nonsense sequences of amino acids. These “nonsense sequences” are then recognized by the immune system which mounts an immune reaction, the “off-target” immune response.

The “ribosomal slippage” can be fixed by removing the pseudo-uridine, and replacing it with plain old uridine, the natural version.

Conclusion: Off-target immune response is a severe flaw in the mRNA vaccine platform which is extremely dangerous and should prompt the withdrawal of the entire product line. Government and media have been blatantly lying to the public for three years now. The mRNA platform is neither safe nor effective as demonstrated in this Cambridge study.

Jeffrey Dach MD
7450 Griffin Road, Suite 190
Davie, Fl 33314

Links and References:

1) Researchers redesign future mRNA therapeutics to prevent potentially harmful immune responses by University of Cambridge Research News

Researchers have discovered that misreading of therapeutic mRNAs by the cell’s decoding machinery can cause an unintended immune response in the body.

mRNA – or ‘messenger ribonucleic acid’ – is the genetic material that tells cells in the body how to make a specific protein. Researchers from the Medical Research Council (MRC) Toxicology Unit have discovered that the cellular machinery that ‘reads’ mRNAs ‘slips’ when confronted with repeats of a chemical modification commonly found in mRNA therapeutics. In addition to the target protein, these slips lead to the production of ‘off-target’ proteins triggering an unintended immune response.

N1-methylpseudouridine – which are currently contained in mRNA therapies – are responsible for the ‘slips’ along the mRNA sequence.

When the ribosome is confronted with a string of these modified bases called N1-methylpseudouridine in the mRNA, it slips around 10% of the time causing the mRNA to be misread and unintended proteins to be produced – enough to trigger an immune response. Removing these runs of N1-methylpseudouridine from the mRNAs prevents ‘off-target’ protein production.

unintended immune response occurred in one third of the 21 patients in the study who were vaccinated

The safety concern for future mRNA medicines is that mis-directed immunity has huge potential to be harmful, so off-target immune responses should always be avoided.”

2) Mulroney, T E et al: ‘(N)1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting.’ Nature, Dec 23.

3) Tom Mulroney Research Associate with the Willis Group (Unit Director, Professor Anne Willis) MRC Toxicology Unit
Gleeson Building Tennis Court Road University of Cambridge, CB2 1QR

Jeffrey Dach MD
7450 Griffin Road, Suite 190
Davie, Fl 33314

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