BioFilms in Chronic Rhino Sinusitis

Nasal SInus Irrigation NasoPureBioFilms in Chronic Rhino Sinusitis

You might be wondering why antibiotics and antifungal drugs are ineffective for chronic sinus infections.  It’s because of the Bio-Film formation.  Biofilms are colonies of microbes that form a mass which is resistant to drug therapy.

A Syndrome Which is Quite Common

Chronic Sinusitis, nasal polyposis, asthma and eosinophilia are quite common and may co-exist as a syndrome.    Chronic bacterial or fungal sinus infection with Bio-Film formation has BioFilms in Chronic Rhino Sinusitis U Pennbeen implicated in this syndrome.  Many of these patients have been on multiple courses of antibiotics and/or antifungal drugs which are completely ineffective because of bio-film formation.    Many of these patients have undergone repeated nasal sinus surgeries, and are commonly steroid dependent from chronic use of prednisone.

Below is a link to a useful Slide Show presentation which discusses BioFilm formation, and newer treatment methods for BioFilm eradication such as baby shampoo surfactant irrigation, light therapy, low level ultrasound, manuka honey irrigation etc,  Additionally, some users feel that Xylitol nasal irrigation is superior to saline, and pulsed Irrigation systems may be superior to the squeeze bottle type systems.  Proteolytic enzymes such as serra-peptidase may be of use in digesting the bio-film.  Probiotics must also be added whenever anti-microbial remedies are used.

Above Left image of biofilm courtesy of U Penn, Below Image CAT Scan showing sinusitis courtesy of Family Practice Notebook.

CAT Scan of SInusitisSlide Show explaining BioFilms: GRAND ROUNDS FEB 19, 2014, Angela Natili, MD  U. of Texas Dept. of Otolaryngology: Click Here: 2014-02-pic-biofilm-and-crs.

Click Here for: Russell Faust MD,  Five step program to eliminate Sinusitis.

NASAL- Sinus  Irrigation

Nasal SInus Irrigation NasoPure2This is a Case Report by Dr Russell Faust showing serial CAT Scans of clearing of sinus cavities over time using simple saline irrigation: 3 Year Old Boy Hospitalized For Severe Sinusitis: Simple Cure.

Buy on Amazon: NasoPure Irrigation System by Dr. Hana R. Solomon, M.D

Xylitol Nasal Irrigation

General info on nasal xylitol from A. H. ‘Lon’ Jones D.O.  Nasal

Xylitol nasal irrigation in the management of chronic rhinosinusitis: A pilot study Joshua D. Weissman MD, Francisca Fernandez MD and Peter H. Hwang MD* The Laryngoscope  Volume 121, Issue 11, pages 2468–2472, November 2011

Buy XClear (Xylitol Irrigation) on Amazon: Xlear Nasal Spray, 1.5 fl oz liquid

Buy Pulsed Nasal Irrigation System on Amazon

Hydro-Pulse Irrigation System Dr Murray Grossan

Enzyme Therapy to Dissolve Bio-Film – InterFase Plus

Buy on Amazon: Specialized enzymes and EDTA disrupt biofilm matrix embedding potential gastrointestinal pathogens. InterFase Plus and Probiotics.

Klaire Labs – Interfase Enzyme Supplement – 120 Veg Caps

Add on probiotics: Prescript-Assist Broad Spectrum Probiotic Prebiotic Complex (60 Caps)


Sublingal Immunotherapy Drops for Allergies: This is a useful book on Amazon for treating underlying Allergies as a cause of asthma: Dr. Dean Mitchell’s Allergy and Asthma Solution: Sublingual Immunotherapy, Allergy Drops.

Articles with related interest:  More on Oregano as anti microbial


Nasal Irrigation:

Clinical Study and Literature Review of Nasal Irrigation. Lance T. Tomooka, Claire Murphy PhD and Terence M. Davidson MD
The Laryngoscope Volume 110, Issue 7, pages 1189–1193, 2000

Buy on Amazon: NasoPure Irrigation System by Dr. Hana R. Solomon, M.D

Web Site for Hana R. Solomon, M.D Nasal Saline Rinse System  (Nasopure),  Dr. Hana’s Nasopure.

Videos on You Tube: How to Use NasoPure Nasal Irrigation System

Buy on Amazon: Water Pic Nasal Sinus  Irrigation System

Eosinophilia is poor prognostic sign:

1) Significance of eosinophilia in chronic rhinosinusitis. American Journal of Rhinology, 2002, Vol 16, Iss 6, pp 313-317. MH Zadeh, V Banthia, VK Anand, C Huang. Anand VK, 205 E 64th St, New York,NY 10021 USA.

2) Eosinophilic inflammation in sputum of poorly controlled asthmatics. European Respiratory Journal, 2002, Vol 20, Iss 6, pp 1370-1377. M Romagnoli, I Vachier, PT delaFuente, H Meziane, C Chavis, J Bousquet, P Godard, P Chanez. Chanez P, Ctr Hosp Univ Montpellier, Hop Arnaud Villeneuve, Clin Malad Resp, Inst Natl Sante & Rech Med, U454, F-34295 Montpellier 5, FRANCE.

3) Clinical factors influencing the eosinophil infiltration of nasal polyps. Rhinology, 2002, Vol 40, Iss 4, pp 173-178. R Jankowski, F Bouchoua, L Coffinet, JM Vignaud. Jankowski R, Henri Poincare Univ, Serv ORL, CHU Cent Hosp, Dept Otorhinolaryngol, 29 Ave Lattre Tassigny, CO 34, F-54035 Nancy, FRANCE

Biofilm Agents Resveratrol, pterostilbene, and baicalein, Ozone, EDTA, Garlic, Enzymes

4) Kolouchová, Irena, et al. “Resveratrol, pterostilbene, and baicalein: Plant-derived anti-biofilm agents.” Folia microbiologica 63.3 (2018): 261-272.

5) Harjai, K “Garlic blocks quorum sensing and attenuates the virulence of Pseudomonas aeruginosa.” FEMS immunology and medical microbiology 58.2 (2010): 161.

6) Liu, Zhenqiu, et al. “In vitro and in vivo activity of EDTA and antibacterial agents against the biofilm of mucoid Pseudomonas aeruginosa.” Infection 45.1 (2017): 23-31.

7) Molobela”Protease and amylase enzymes for removal and degradation of Pseudomonas fluorescens biofilm.” African J of Microbiology Resh4.14 (2010): 1515.

8) Delgado-Roche “Ozone oxidative preconditioning prevents atherosclerosis development in New Zealand white rabbits.” J Cardiovasc Pharm 2013

In Testing for Allergies, a Single Shot May Suffice
By LAURIE TARKAN Published: March 20, 2007

Broward Center for Allergy and Sinus Dr Callari : Sublingual Immunotherapy

Richard H. Callari, MD,
Broward Sinus & Allergy Center
1625 S.E. 3rd Avenue, Suite 717
Fort Lauderdale, FL 33316
Phone: (954) 760-7836
Fax: (954) 760-7869

Angela Natili, MD  THE UNIVERSITY OF TEXAS DEPARTMENT OF OTOLARYNGOLOGY.  GRAND ROUNDS FEB 19, 2014  Francis B. Quinn, Jr., MD, FACS,  Melinda Stoner Quinn, MSICS  2014-02-pic-biofilm-and-crs

Xylitol Nasal Irrigation

Xylitol nasal irrigation in the management of chronic rhinosinusitis: A pilot study Joshua D. Weissman MD, Francisca Fernandez MD and Peter H. Hwang MD* The Laryngoscope  Volume 121, Issue 11, pages 2468–2472, November 2011

Buy XClear on Amazon: Xlear Nasal Spray, 1.5 fl oz liquid

Link to this article:

Jeffrey Dach MD
7450 Griffin Road, Suite 190
Davie, Fl 33314

Serving Areas of: Hollywood, Aventura, Miami, Fort Lauderdale, Pembroke Pines, Miramar, Davie, Coral Springs, Cooper City, Sunshine Ranches, Hallandale, Surfside, Miami Beach, Sunny Isles, Normandy Isles, Coral Gables, Hialeah, Golden Beach ,Kendall,sunrise, coral springs, parkland,pompano, boca raton, palm beach, weston, dania beach, tamarac, oakland park, boynton beach, delray,lake worth,wellington,plantation

Last updated on by Jeffrey Dach MD

BioFilms in Chronic Rhino Sinusitis
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BioFilms in Chronic Rhino Sinusitis
BioFilms in Chronic Rhino Sinusitis
Jeffrey Dach MD
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8 thoughts on “BioFilms in Chronic Rhino Sinusitis

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  4. Baking soda solutions with Lugols Iodine are the best for dissolving these biofilms. 3 tsp baking soda, 2 drops Lugol
    s 5% in 3 cups sterile water

  5. Pingback: Atherosclerotic plaque as infected biofilm | 2RUTH NETWORK | 2RUTH NETWORK

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  7. From a reader on Facebook (VLC)

    Dear Dr Dach,

    After suffering with a severe sinus infection for about two weeks, my Integrative Doc shared the link to the Baylor Med study on the use of baby shampoo irrigation (to bust biofilms).
    I combined that therapy twice a day, plus used the Xclear spray twice a day, and added 2 drops of Lugols Iodine to the second rinse of the day. In just 48 hours I went from extreme painful infection to able to breath with no pain. After another 36 hours the infection was GONE!
    It works!!

    From VLC

    New ways to flush out sinus infections Baylor College of MedicineBaylor College of Medicine NewsHead and NeckNew ways to flush out sinus infections Julia Parsons Houston, TX – Apr 6, 2015

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