Salvestrols Nutritional Supplements for Cancer Survivors
by Jeffrey Dach MD
Since it is so close and convenient, I go every year to ACAM’s annual Spring meeting at the Westin Diplomat resort here in Hollywood on the beach.
Sometimes the most useful information doesn’t come from the speakers at the podium selected by the ACAM staff. Rather the most useful information may come to you from other doctors attending the meeting.
This was the case last week when I saw Michael Schachter MD at the meeting. and had a chance to catch up since last year. In brief conversation, Dr Michael Schachter mentioned a new anti-cancer nutritional supplement called Salvestrols. He asked me if I had heard about it. I said no, not really. So, he then proceeded over the next few minutes to fill me in on Salvestrols, the topic of this article.
Above left image: courtesy of Michael B Schachter MD web site.
Left image book cover courtesy Dr. Schaefer. Salvestrols: Nature’s Defence Against Cancer.
What are Salvestrols ?
Salvestrols are naturally occurring extracts of fruits and vegetables which are metabolized by the CYP1B1 enzyme in cancer cells. While harmless to normal cells, these metabolites will kill cancer cells in a process called apoptosis. These are not drugs. These are very safe nutritional supplements.
A Brief History of the Discovery of the CYP1B1 Enzyme System
They discovered that all cancer cells over-express enzyme CYP 1B1 activity, whereas normal healthy cells do not have this enzyme in appreciable amounts. These two scientist then spent decades working out assays this enzyme, as well as tests and drugs that affect this enzyme system.
Impatient with the length and expense of the drug approval process, Drs. Burke and Potter turned to the natural plant world, and discovered plant compounds which are metabolized by the CYP 1B1 in 2002, calling them “Salvestrols”, a Latin word translated as “to save”. There are 100,000 phytochemicals in nature . Fewer than 50 will be Salvestrols which are metabolized by CYP 1B1 capable of killing cancer cells.
“Standard therapeutic dosing falls between 4,000 and 6,000 points per day depending on the patient’s body mass index (BMI).” (5)
Randomized Trials Vs. Case Reports
Salvestrols are natural supplements of no interest to the pharmaceutical industry, and therefore, no funding for expensive controlled trials. The fact is, we may never have the benefit of randomized trials of Salvestrols to judge its effectiveness. This leaves us in a quandary. How are we to evaluate whether or not this is an effective treatment for cancer? The answer to this question lies in case reports and observational studies.
Salvatrols case reports from the Journal of Orthomolecular Medicine (Vol. 22, No. 4, 2007) (6A) Savestrol Cases Studies_JOM_2007_v22_n04_p177
Case 1. Lung Cancer
A 69-year-old male coughing up blood had bronchoscopy and biopsy confirming inoperable, stage 2-3 squamous-cell carcinoma of the lung. Imaging showed a seven-centimeter chest wall mass with enlarged nodes. The cancer was deemed untreatable and no chemotherapy or radiation therapy recommended.
This patient immediately commenced a diet of fresh, organic fruit, vegetables and juices. Meat, refined sugar and dairy products were eliminated from his diet. In addition, he began Salvestrol supplements (4000 points) per day for six weeks.
At the end of the first week, he was no longer coughing up blood. Within three weeks his diagnosis had been changed from inoperable to operable lung cancer. At the end of three weeks a biopsy of the largest lymph node was taken following a PET scan and it was found to be negative. The diagnosis was again changed to operable lung cancer requiring removal of one lobe of the affected lung.
Six weeks later the patient underwent surgery. The chest surgeon removed the shrunken tumor and a couple of suspicious lymph nodes. During surgery the tumor was found to be clear of the chest wall. Postoperative pathology of the lymph nodes was negative for cancer, and the patient was deemed cancer free.
Published in the Journal of Orthomolecular Medicine (Vol. 22, No. 4, 2007) by Brian Schaefer, Hoon Tan, Dan Burke, and Gerard Potter.
Case 2. Melanoma
A 94-year-old woman was diagnosed with stage 4 melanoma on her foot following a biopsy. The melanoma was deemed to be inoperable.
Upon returning home the family started her on a course of Salvestrols, Four (1,000 point) Salvestrol capsules were taken per day,
One year later a physicians visited the woman and found the melanoma was gone and the foot completely healed. The woman was deemed to be cancer free.
Published in the Journal of Orthomolecular Medicine (Vol. 22, No. 4, 2007) by Brian Schaefer, Hoon Tan, Dan Burke, and Gerard Potter.
Salvestrol case reports from Journal of Orthomolecular Medicine 25 2010 Dr Brian Schaefer (2)
Case #1. Stage 3 breast cancer- Tumor shrinks 50% on Salvestrols.
A 50-year-old female with a 2.5 cm tumor in the left breast, biopsy proven stage 3 breast cancer. Surgical removal was recommended and a surgery date was scheduled for one month later. Chemotherapy was declined, At the time of original biopsy diagnosis, the patient began Salvestrols (3,500 points per day) taken before meals for three months.. Also, the patient started organic, vegan diet (vegetables, greens, fruits, juices, wheatgrass and tea) and an exercise program of walking and yoga. Salvestrol specific supplements were also taken; biotin, 300mcg; niacin, magnesium by way of a calcium/magnesium tablet, iron,and Vitamin C, 1,000 mg. and selenium (200 mg)
During the one-month wait for surgery, the patient reported the tumor softened, the texture changed and the tumor progressively decreased in size.
At surgery, a the tumor was only 1.3 cm in size, half the diameter one month earlier. The lymph nodes were negative.
One month after surgery, the patient underwent radiotherapy once a day for 30 days, as a preventive measure. She declined chemotherapy.
After three months, Salvestrol dosage was reduced to 2,100 points daily.
13 months after surgery, the patient remains cancer free
Conclusion : Tumour shrinkage during the one-month wait for surgery appears to be due to Salvestrol supplementation, nutrition, and exercise.
Case #2. Stage 2 liver cancer treated with hepatic artery embolisation.
A 73-year-old Korean male with with loss from alcoholic cirhosis had three intrahepatic masses discovered on CAT scan thought to be metastatic hepatoma.
One month later patient started Salvestrol supplements per day (4,200 points per day) for four months. and then reduced to 2,100 points per day). In addition to the Salvestrol supplementation, he began IV vitamin C injections (30 g weekly). This dose was increased gradually to 100 g per week. He also took Niacin for four months after his diagnosis, 250 mg per day for one month and then increased this amount to 500 mg per day for about five months. Eleven months after commencing Salvestrol supplementation he was declared ‘all clear’, cancer free. This case leaves Salvestrol supplementation, high dose Vitamin C, niacin, exercise and mental outlook as the possible candidates to explain his recovery.
Case #3. Colon cancer-clinical diagnosis- no pathologic confirmation
A 64-year-old female with weight loss and abdomenal pain, and distention, blood in the stool and jaundice. Colon cancer was suspected however, the patient declined testing to confirm the diagnosis. She immediately started taking Salvestrols, (3,150 points per day) was maintained for three months. In addition to the Salvestrol supplementation she took a daily multivitamin, one ‘colon green’ capsule per day, one S-adenosyl L-methionine capsule per day and used externally applied castor oil packs on the abdomen four days each week. She reported feeling better within three weeks of Salvestrol supplementation. By seven weeks the abdominal pain and distention had subsided. After seven months of Salvestrol supplementation she was back to normal, attributes her recovery to the Salverstrol Supplements.
Case #4. Prostate cancer- PSA Climbing
A 72-year-old male had been diagnosed with prostate cancer based on climbing PSA (prostate specific antigen). To confirm the diagnosis, patient had a
positive uPM3™13 urine-based genetic test for prostate cancer from Bostwich Laboratories. This test for the PCA3 gene was positive for prostate cancer.
Patient started Salvestrol supplementation with other nutritional supplements: vitamin C; Co-Q10; folic acid; garlic; lycopene; zinc; cranberries; 2 multivitamins without iron; and vitamin E.
Salvestrol dosage With breakfast on Monday, Wednesday and Friday – one Salvestrol Gold (1000 point) capsule.
After a period of three months of Salvestrol Supplementation, PSA test results had returned to within normal limits. PSA tests every three months for one year were all within normal limits.
I have summarized a few more case reports published by Dr. Schaefer in the Journal of Orthomolecular Medicine Sept 2012 . (5)
Case #1: Stage 1 Breast Cancer – Remission after Salvestrols (5)
A 76-year-old female noticed multiple lumps at the surface of her right breast while showering, and biopsy confirmed breast cancer. The patient declined conventional treatment with Femara® (letrozole),an aromatase inhibitor. Instead, The patient started a three week course of 1,400 Salvestrol points daily. One capsule AM with breakfast and one PM, with no additional supplements, alternative treatments, or prescription medications, and no other dietary or lifestyle changes were made.
The patient reported that after 10-12 days of Salvestrol supplementation, breast self-examination revealed the lumps had decreased in size. During the third week of Salvestrol supplementation breast self examination revealed the breast lumps could no longer be felt. There were no adverse side effects from the Salvestrol supplementation. A month after her diagnosis computerized tomography (CAT) and mammograms showed no abnormality. The patient was declared cancer free.
#2 Squamous cell carcinoma the Anus-responds to Salvestrols (5)
A 46-year-old male was diagnosed with biopsy proven squamous cell carcinoma of the anus. Surgery was recommended and declined by the patient. Instead, the patient started twice weekly applications of Aldara® (imiquimod) cream.
Seven years later, squamous cell carcinoma was again confirmed by a repeat biopsy, and again surgery was recommended and declined.
Three years after the second biopsy diagnosis, the anal lesions were appearing much more frequently.
The patient began Salvestrols and XM8 cream (i.e., a natural borage oil based cream) and stopped use of Aldara®.
For three months the patient took one Salvestrol Platinum (1,000 points) capsule per day and applied XM8 cream every two to three days.
After six weeks of Salvestrol use, the lesions were no longer visible. At the end of three months of Salvestrol use, the patient was deemed to be all clear.
Case #3: Chronic Lymphocytic Leukemia – enlarging nodes- declined radiotherapy after Salvestrol response (5)
An 80-year-old woman presented with a 7 cm left neck mass, and enlarged inguinal and axillary nodes. Biopsy confirmed chronic lymphocytic leukemia.
Her condition declined with severe pain in her throat and weight loss. A second biopsy of the throat lesion showed ulcerated tonsil with chronic lymphocytic leukemia. She was referred for radiotherapy. She noted progression of disease in the nexk inguinal and axillary areas.
At this point, the patient started a three month course of Salvestrols with two Salvestrol Platinum (1,000 point) capsules per day. One AM with breakfast and one PM with dinner. She also modified her diet to include more fruits and vegetables.
After one month of Salvestrol supplementation, the patient was feeling better. The enlarged nodes had started to soften and shrink. This improvement prompted the patient to decline radiation therapy.
After two months of Salvestrol supplementation, the tumour in her neck had almost disappeared. At the end of the third month of Salvestrol supplementation the tumours in her neck had completely disappeared. The oncologist reported no evidence of cancer.
Case #4: Benign Prostatic Hyperplasia – response to Salvestrols
A 50-year-old male with BPH had reduced flow and nocturia. PSA was wnl. The patietn was treated with 0.4 mg, of the alpha-adrenergic blocker, Flomax® (tamsulosin). However he had adverse side efefects and discontinued. He then started taking one Salvestrol Gold capsule (350 points) each morning.
Within a month the incidence of nocturia had dropped down to once a night,
He reported stronger urinary flow. After three months of Gold the patient switched to Salvestrol Platinum (1,000 points per capsule). He reported that there was a noticeable improvement in terms of decreased incidence of nocturia and increased strength of flow.
Case #5: Stage 3 Primary Peritoneal Carcinoma-Combined Chemotherapy, surgery and Salvestrols- Complete Remission
A 57-year-old female presented with abdominal distention, loss of appetite, and fatigue. CA-125 was very high, 7,250, and biopsy revealed peritoneal carcinoma, with involvement of the ovaries. The patient then started IV chemotherapy Paclitaxel (for three hours) followed by Carboplatin (for one hour) every three weeks. Ondansetron was prescribed twice daily for two days following chemotherapy to manage nausea and vomiting;
At the same time as the starting chemotherapy, the patient also started three Salvestrol Platinum (2,000 point) capsules per day (total of 6,000 Salvestrol points per day).
One week after starting her chemotherapy and Salvestrols there was a significant reduction in her abdominal swelling.
By week four her CA-125 level had dropped to 4,593.
Her CA-125 level was measured the day she received her third course of chemotherapy (week seven from onset of treatments) and it had dropped to 510.
Her physician noted that she had never seen such a huge fall in CA-125 levels in all her career and was quite taken aback by the results thus far.
During the twelfth week of treatment she received a hysterectomy. The surgeon reported that most of the cancer had been removed except for small residuals. Three weeks after the surgery the CA-125 level had fallen further to 52.
By week 19 of her treatment, the CA-125 had fallen to within normal limits.
Chemotherapy was completed during week 22, and the CA-125 level was measured as 15 (within normal limits).
At week 25 the CA-125 had fallen to 13.
A CT scan was performed during week 28 and the patient was deemed cancer free with a CA-125 level of 11.
This is a very impressive response for stage 3 peritoneal cancer or ovarian cancer following combined treatment with chemotherapy, hysterectomy and Salvestrols.
Conclusion: Case studies on the use of Salvestrols for cancer prevention and treatment are impressive. Have you used Salvestrols? Email to me your experience. using the reply box below this post.
Author: Jeffrey Dach MD
Links and References
pdf files on Salvestrol
Annual International Conference 39th Orthomolecular Medicine Today Early Cancer Detection By Brian Schaefer, D.Phil.(Oxon) ISOM Annual International Conference: 39th Orthomolecular Medicine Today. April 30 – May 2, 2010. Hotel Vancouver, Vancouver, B.C.
2) salvestrol_case_studies JOM_25_2010_Schaefer
Journal of Orthomolecular Medicine Vol 25, No. 1, 2010 (with authors Brian A. Schaefer, D.Phil.,Catherine Dooner, B.A, M. Danny Burke, Ph.D, Gerard A. Potter, Ph.D)
3) Salvestrol Update 2012 Ware
Salvestrol Update INTERNATIONAL HEALTH NEWS
William R. Ware, PhD – Editor
NUMBER 229 JULY/AUGUST 2012 21ST YEAR
4) Dr. William R Ware-salvestrols-issue-30
Salvestrols A natural, targeted approach to preventing and treating cancer
By William R. Ware, Ph.D. Faculty of Science
University of Western Ontario London, Ontario, Canada
Issue 30 Jounal of IHP nov dec 2012
Cancer and Related Case Studies Involving Salvestrol and CYP1B1
September 2012 Journal of Orthomolecular Medicine;2012, Vol. 27 Issue 3, p131
Schaefer, Brian A.; Potter, Gerard A.; Wood, Robbie; R.C.S., D.Orth.; R.C.P.S, D. D. Orth.; Burke, M. Danny
6) Salvestrol+testing+journal of Phytotherapy_IJOP_SPRING_2013-1
SPRING 2013. IJOP. The International Journal Of Phytotherapy
6A) Savestrol Cases Studies_JOM_2007_v22_n04_p177
Salvatrols case reports from the Journal of Orthomolecular Medicine (Vol. 22, No. 4, 2007)
7) Salvestrols: Nature’s Defence Against Cancer: Linking Diet and Cancer 2012 by Dr. Brian A Schaefer
Professor Danny Burke
Salvestrols are a new class of natural compounds that have a pharmacological definition rather than a chemical definition. They are defined by the action of the metabolites produced when they are metabolised by the CYP1B1 enzyme in cancer cells. Simply put, salvestrols are food-based compounds that are metabolised by CYP1B1 to produce metabolites that are anticancer agents. These anticancer agents suppress tumour growth by killing the cancer cells. Salvestrols provide an explanation of the link between diet and cancer and between fruit and vegetable consumption and lower cancer incidence. There has to be a significant change in the way that we approach food, in the way we grow food and the way that we see our diet. Anthony Daniels – I never believed that cancer was a curable disease. Now, in the light of what we have discovered, I believe that cancer is curable.