Regression of Calcium Score Using Cyclodextrin by Jeffrey Dach MD
Regression of calcium score is the goal of our calcium score program described in previous newsletters and books. (See articles with related interest below). I received this Press Release email from Kyle Hodgetts at the Cholrem Company (Australia) announcing the publication of their new study showing exactly that, regression of calcium score with their cyclodextrin product. I learned about this from James Roberts, MD, an integrative cardiologist who was involved in the study. Note: I have no financial interest in the Cholrem company or any cyclodextrin product.
Header Image: Courtesy of Wikimedia Commons. CC 4.0. An illustration of a man feeling tightness or pain in the chest – a symptom of angina or of a heart attack. August 2019. Source and Author: https://www.myupchar.com/en.
Here is the email. Thanks and credit for the email goes to the Cholrem Company:
The Holy Grail of Cardiology Has Arrived
PRESS RELEASE • JAN 21, 2026 07:40 EST
Peer-Reviewed Paper Confirms Cavadex Drives Plummeting Coronary Artery Calcium Scores : Reversing the Irreversible
ROBINA AND QUEENSLAND, AUSTRALIA, January 21, 2026 (Newswire.com) – Today marks one of the most profound moments in the history of cardiovascular medicine.
A newly published, peer-reviewed multi-center retrospective case series has delivered irrefutable evidence that high-viscosity 2-Hydroxypropyl-β-cyclodextrin (Cavadex) can reverse established coronary artery calcification, a biological outcome long considered impossible.
Published Paper:
Longitudinal Retrospective Analysis of High-Viscosity 2-Hydroxypropyl-β-Cyclodextrin (Cavadex) in the Regression of Atherosclerotic Cardiovascular
For more than 30 years, the cardiology world has operated under an unbreakable rule:
Once coronary artery calcium (CAC) appears on a CT scan, it never goes down.
It only increases – year after year, relentlessly – at typical annualized rates of 14-25% (often 20-30% in high-risk patients). Spontaneous, clinically significant regression is virtually unheard of in the scientific literature. Even the most powerful lipid-lowering drugs – high-intensity statins, PCSK9 inhibitors, ezetimibe combinations – do not reverse CAC scores. At best, they slow the rise; at worst, they accelerate densification and push scores higher.
That era is over.
In this real-world evidence cohort, patients using the proprietary high-viscosity rectal formulation of Cavadex achieved dramatic, objective plummeting of CAC scores:
Absolute reductions of up to **320 points** within approximately 12 months
One patient reversed a consistent **+27-28% annual progression** to **-10.5% regression** – a nearly 40-percentage-point swing in disease trajectory
Net regression magnitudes that dwarf expected progression (e.g., -865 units versus a projected +545-unit increase)
Rapid structural reversal in select cases, including a **70-point drop** in just **9 weeks**
These are not subtle statistical blips. These are biological reversals of calcified plaque burden, the very hallmark of advanced atherosclerosis long thought to be permanent scar tissue.
“This is the holy grail we have been searching for,” said lead author Kyle Hodgetts.
“We are no longer talking about slowing disease or stabilizing vulnerable plaques. We are witnessing rapid active removal of decades of accumulated calcification, something no therapy in the history of cardiology has reliably achieved.”
Why This Changes CVD Treatment Forever
Coronary artery calcium is the single most powerful non-invasive predictor of heart attack, stroke, and cardiovascular death. A therapy capable of driving CAC scores downward fundamentally alters the treatment landscape:
For the first time, “end-stage” patients with refractory angina, diffuse multivessel disease unsuitable for stenting or bypass, or statin intolerance may have a real disease-modifying option.
The potential to prevent millions of major adverse cardiovascular events worldwide, extending healthy lifespans and slashing the global burden of the planet’s #1 killer (over 19 million deaths annually).
A shift from the decades-old paradigm of “manage progression” to the new reality of “reverse the disease.”
The mechanism: direct solubilization of sub-endothelial cholesterol crystals, deactivation of NLRP3-driven inflammation, and enhanced cholesterol efflux from plaque macrophages – aligns perfectly with the observed CAC regression and offers a completely novel pathway beyond LDL-receptor modulation.
The published data is consistent and profound.
Cardiology textbooks will need to be rewritten. The wait for a true reversal therapy in atherosclerosis is over.
Media & Professional Inquiries:
Kyle Hodgetts
Cholrem Pty Ltd
Email: admin@cholrem.com
========== End of Press release Email =====================
Dr. James Roberts and Cyclodextrin
Dr. James Roberts has been using such a drug called Cyclodextrin (cavadex) which actually removes oxidized cholesterol from the atherosclerotic plaque and available studies show efficacy for reducing angina symptoms and for reducing calcium scores. See this link to view Dr. Roberts’s video presentation (once there, scroll down to the bottom of the page).
A Patient with Resolution of Angina after Treatment with CycloDextrin
Mr. Smith is such a patient with calcium score progression of 46 percent annually, and a new onset of angina symptoms. His Lp(a) is markedly elevated. CAT angiogram shows significant stenosis of a branch of the LAD (left anterior descending) coronary artery, probably causing the angina. After two weeks of cyclodextrin treatment, his angina resolved. (8-26)
In 2021, Dr. Guo Chen summarized the cardiovascular benefits of and mechanism of action of cyclodextrin, writing:
1) [Cyclodextrin] enhanced cholesterol efflux from atherosclerotic plaques/macrophages (Zimmer et al. 2016),
2) [Cyclodextrin] inhibited oxidation of plasma LDL (Ao et al. 2016a; Ao and Chen 2017)
3) increased level of plasma HDL (Wang et al. 2019),
4) reduced cholesterol crystal-induced complement activation (Pilely et al. 2019)
5) modified gut flora (for oral administration) (Sakurai et al. 2017).
6) we found that MβCD [cyclodextrin] could impair the monocyte-adhering ability of normal endothelial cells by influencing adhesion molecules and cytoskeleton (Ao et al. 2016b). (9)
Emails Received by Kyle at Cavadex (Cyclodextrin)
Here is just a small sample of some of the latest emails from your fellow Cavadex users:
-
- Massive Blockage Reduction: One user, Larry, saw his blockage reduce from 83% down to 28% according to his cardiologist. Another user, Andrew, saw his plaque drop from 51 to 29.4.
- Calcium Scores Dropping: Gayle and Stephen reported a Calcium Score drop from 100 down to 60, noting a specific reduction in the Right Coronary Artery. Jim saw a total regression of 67 points relative to his previous progression rate over the period he used Cavadex.
- Angina Vanishing: Karenlee, who used to suffer frequent attacks, has gone over 18 months without a single angina event. Paul went from having warning pain after walking 50 meters to now walking over a mile briskly with no ill effect.
- Clear Arteries: Brett, who has a history of aggressive atherosclerosis, reported that after his 7th coronary angiogram, his arteries were totally clear, amazing his cardiologist.
It isn’t just about the numbers. It is about getting your life back.
It is about Chris, who refused bypass surgery and is now exercising in the water 3 times a week. It is about Jack, 73 years young, who went from using a cane to walking miles and touching his toes. It is about Jim noting a definite improvement in ED and blood flow.
Articles with related interest:
Coronary Artery Disease, Questions and Answers
Calcium Score Determines Who to Treat With Statin Drug
Calcium Score, Paradigm Shift in Cardiology
Calcium score Benefits of Aged Garlic
All previous articles on Heart Disease and Calcium Score
Heart Book: How to Keep Your Heart Healthy by Jeffrey Dach MD
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Heart Book is a journey through the confusing maze of literature on coronary artery disease, the number-one killer in America. With his years of practice in vascular radiology, Dr. Dach has the background, credentials, and experience to transform your understanding of heart disease. The old medical paradigms have been upended, yet mainstream cardiology clings to these tired dogmas as if nothing has changed. Dr. Dach paints the big picture using a brand new brush. Be prepared to be shocked, amazed, provoked, and gratified as this book empowers you to take control of your own heart health.
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