Podcast Carol Petersen and Jeffrey Dach MD Bioidentical Hormones 101 Second Edition (2025)
Join Carol Petersen as she interviews Dr. Jeffrey Dach, a renowned expert in bioidentical hormones, about his newly updated book “Bioidentical Hormones 101” second edition (2025). In the interview, we discuss the 2022 study by Dr. Shuyuan Huang who calculated if all women in the US using oral estrogen switched to topical estrogen (transdermal), then 2,245 ischemic strokes per year could be prevented. (1)
We also discussed the Women’s Health Initiative (WHI) Study showing increased breast cancer in the first arm study using Premarin (CEE) with medroxyprogesterone (MPA) of 24 percent (nonsignificant) (hazard ratio [HR] 1.24, 95% CI 1.01–1.53) compared to placebo. (2)
Second Arm WHI shows 45% Reduction in Breast Cancer Mortality
However, for the second arm of the WHI study using Premarin (CEE) alone, the 18 year follow up showed a 45 percent reduction in breast cancer mortality (significant) (hazard ratio [HR] 0.55, 95% CI 0.33–0.92). This indicates estrogen is highly protective and does not cause breast cancer. This is a paradigm shift in our thinking about breast cancer. I would also point out that this 45 percent reduction in breast cancer mortality is larger than any mammography breast cancer screening program, which is in the range of 20-30 percent reduction for breast cancer mortality, according to Dr. Nils Bjurstam (2003). This 45 percent reduction in breast cancer mortality is also larger than any primary prevention study using antiestrogens (tamoxifen or aromatase inhibitors), none of which show any significant reduction in breast cancer mortality. (3-8)
What went wrong with the HABITS STUDY by Lars Holdmerg of Sweden?
We also discussed the HABITS study of Lars Holmberg from Sweden in which breast cancer survivors on tamoxifen were given HRT (estradiol plus norethisterone a synthetic progestin) and compared to non-users. This was the only one of 26 studies of HRT in Breast Cancer Survivors compiled by Avrum Bluming MD which showed an increased breast cancer recurrence in the hormone treated group. All breast cancer recurrence was in tamoxifen users, indicating the development of anti-estrogen resistance. Using the work of Zsuzsanna Suba, a Hungarian pathologist, who writes about the three phases of anti-estrogen resistance, I speculate that this is just another example of the final phase of estrogen resistance with breakthrough of proliferative breast cancer caused by blockade of both the estrogen and androgen receptors. The tamoxifen blocks the estrogen receptors, and the norethisterone (progestin) blocks the androgen receptors.
The HABITS (Hormonal Replacement Therapy After Breast Cancer—Is It Safe?) by Lars Holmberg in Sweden, studied hormone replacement therapy (HRT) in breast cancer survivors (women with a history of breast cancer). The randomized trial compared HRT (primarily estradiol with norethisterone) in 442 breast cancer survivors compared to non-users. After 4 years, the study found an approximate 3-fold increase in new breast cancer events (39 events in the HRT arm [17.6%] vs. 17 in the control arm [7.7%]). (9-10)
The second edition ebook is expanded into three volumes on Kindle. The paperback version contains all three volumes in one comprehensive print edition.
Here is the cover for the paperback version:
Click Here for link to books on Amazon:
ebook Bioidentical Hormones 101 Second Edition (2025) by Jeffrey Dach MD. This is a Three Volume Series e-book
Paperback Version of Bioidentical Hormones 101 second edition (2025). The paperback contains all three volumes.
Free Video Introduction to Book:
Introduction Video to Bioidentical Hormones 101 Second Edition (2025)
Bioidentical Hormones for Breast Cancer Survivors Video Presentation
Articles with Related Interest:
Hormone Replacement for Breast Cancer Survivors Part One
Hormone Replacement for Breast Cancer Survivors Part Two
Estrogen Metabolism, Iodine, 2MEO Part Three
Testosterone for Breast Cancer Prevention and Treatment
All Bioidentical Hormone Articles
Jeffrey Dach MD
7450 Griffin Road, Suite 190
Davie, Fl 33314
954-792-4663
my blog: www.jeffreydachmd.com
Links and References:
1) Huang, Shuyuan, et al. “Research Progress on The Role of Hormones in Ischemic Stroke.” Frontiers In Immunology 13 (2022): 1062977.
2) Rossouw, Jacques E., et al. “Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women’s Health Initiative randomized controlled trial.” Jama 288.3 (2002): 321-333.
3) Chlebowski, Rowan T., et al. “Association of menopausal hormone therapy with breast cancer incidence and mortality during long-term follow-up of the women’s health initiative randomized clinical trials.” Jama 324.4 (2020): 369-380.
4) Manson, JoAnn E., et al. “Menopausal hormone therapy and long-term all-cause and cause-specific mortality: the Women’s Health Initiative randomized trials.” Jama 318.10 (2017): 927-938.
5) Hodis, Howard N., and P. M. Sarrel. “Menopausal hormone therapy and breast cancer: what is the evidence from randomized trials?.” Climacteric 21.6 (2018): 521-528.
6) Bjurstam, Nils, et al. “The Gothenburg Breast Screening Trial.” Cancer: Interdisciplinary International Journal of the American Cancer Society 97.10 (2003): 2387-2396
7) Cuzick, Jack, et al. “Selective oestrogen receptor modulators in prevention of breast cancer: an updated meta-analysis of individual participant data.” The Lancet 381.9880 (2013): 1827-1834.
8) Cuzick, Jack, et al. “Anastrozole for prevention of breast cancer in high-risk postmenopausal women (IBIS-II): an international, double-blind, randomised placebo-controlled trial.” The Lancet 383.9922 (2014): 1041-1048.
9) Holmberg, Lars, et al. “Increased risk of recurrence after hormone replacement therapy in breast cancer survivors.” Journal of the National Cancer Institute 100.7 (2008): 475-482.
10) Suba, Zsuzsanna. “The pitfall of the transient, inconsistent anticancer capacity of antiestrogens and the mechanism of apparent antiestrogen resistance.” Drug design, development and therapy (2015): 4341-4353.
============================================================
More Links:
Get the book: [Bioidentical Medical Hormones 101 on Amazon] (https://amzn.to/41kSvcs) (Kindle Volumes 1-3 or Print Edition)
‘Dr. Dach’s Website: [JeffreyDachMD.com](https://jeffreydachmd.com/) (Check out Carol’s original testimonial here!)
Related Books Mentioned:
- Cracking Cancer Toolkit by Dr. Jeffrey Dach: [Amazon Link](https://amzn.to/4ouxxlx)
- Hormone Deception by Lindsey Berkson: [Amazon Link](https://amzn.to/45zrAMu)
- Iodine: Why You Need It by Dr. David Brownstein: [Amazon Link](https://amzn.to/4froair)
Other Resources:
- Women’s Health Initiative Study (2017 Follow-Up): [JAMA Article](https://jamanetwork.com/journals/jama…)
- Carol Petersen’s Website: [TheWellnessByDesignProject.com](https://thewellnessbydesignproject.com/) (For more on hormones and wellness)
Bioidentical Hormones 101: A Comprehensive Guide: Unraveling the Confusion [Carol’s Review of Jeffrey Dach’s Books] (https://thewellnessbydesignproject.co…)
Jeffrey Dach MD
7450 Griffin Road, Suite 190
Davie, Fl 33314
954-792-4663
my blog: www.jeffreydachmd.com
Bioidentical Hormones 101 Second Edition
Menopausal Hormone Replacement, Health Benefits
Natural Thyroid Toolkit by Jeffrey Dach MD
Cracking Cancer Toolkit by Jeffrey Dach MD
Heart Book by Jeffrey Dach MD
www.naturalmedicine101.com
www.bioidenticalhormones101.com
www.truemedmd.com
www.drdach.com
Click Here for: Dr Dach’s Online Store for Pure Encapsulations Supplements
Click Here for: Dr Dach’s Online Store for Nature’s Sunshine Supplements
Web Site and Discussion Board Links:
jdach1.typepad.com/blog/
disc.yourwebapps.com/Indices/244066.html
disc.yourwebapps.com/Indices/244067.html
http://sci.med.narkive.com/covV2Qo2/jeffrey-dach-book-announcment-natural-medicine-101
The reader is advised to discuss the comments on these pages with his/her personal physicians and to only act upon the advice of his/her personal physician. Also note that concerning an answer which appears as an electronically posted question, I am NOT creating a physician — patient relationship. Although identities will remain confidential as much as possible, as I can not control the media, I can not take responsibility for any breaches of confidentiality that may occur.
Copyright © 2025 Jeffrey Dach MD All Rights Reserved. This article may be reproduced on the internet without permission, provided there is a link to this page and proper credit is given. See Repost Guidelines.
FAIR USE NOTICE: This site contains copyrighted material the use of which has not always been specifically authorized by the copyright owner. We are making such material available in our efforts to advance understanding of issues of significance. We believe this constitutes a ‘fair use’ of any such copyrighted material as provided for in section 107 of the US Copyright Law. In accordance with Title 17 U.S.C. Section 107, the material on this site is distributed without profit to those who have expressed a prior interest in receiving the included information for research and educational purposes.
Serving Areas of: Hollywood, Aventura, Miami, Fort Lauderdale, Pembroke Pines, Miramar, Davie, Coral Springs, Cooper City, Sunshine Ranches, Hallandale, Surfside, Miami Beach, Sunny Isles, Normandy Isles, Coral Gables, Hialeah, Golden Beach ,Kendall,sunrise, coral springs, parkland,pompano, boca raton, palm beach, weston, dania beach, tamarac, oakland park, boynton beach, delray,lake worth,wellington,plantation
Discover more from Jeffrey Dach MD
Subscribe to get the latest posts sent to your email.
Leave a Reply
You must be logged in to post a comment.