HPV Vaccine, The Greatest Medical Scandal of Our Time

HPV vaccine for your 11 year old son and daughter may soon be mandatory in your state thanks to the combination of two very bad things.

The first bad thing is criminal activity by drug makers Merck and Glaxo Smith Kline (GSK) that manufacture Gardasil and Cervarix.  These criminal activities involve marketing a vaccine as a cancer preventive when no long term studies have been done to show this. The vaccines were approved without proper safety testing or long term safety monitoring. The HPV vaccines are in fact, causing harm to young women who have no recourse in the US since vaccine manufacturers are exempt from liability by Congressional mandate. However outside the US, criminal charges have been filed against the vaccine manufacturers in Spain.(18)  Japan and other countries have curtailed advertising and have reduced use of these vaccines.(21)(25,26)(32)

Note: On Nov 26, 2021, Japan resumed active recommendation of the  HPV vaccine, which had been suspended since June, 2013. (86)

The second very bad thing is the deplorable stupidity of your elected state representatives who after being spoon fed vaccine marketing propaganda have been deceived into proposing mandatory HPV vaccination for all 11 year old school girls and boys.  The net result could very well be one of the greatest medical scandals in history.

Diane Harper MD on HPV Vaccine Efficacy

Diane Harper, the most authoritative expert on HPV Vaccine,  was principle investigator for Merck’s Gardasil and GSK’s Cervarix Clinical trials used for FDA approval. She later became whistle blower and went public with information indicating the vaccines are dangerous and useless for prevention of cervical cancer. Diane Harper is a professor and chair of the department of Family and Geriatric Medicine at the University of Louisville.

HPV Vaccine only Temporary Immunity

In this video from 2011, Diane Harper MD expresses her concern that HPV vaccines provide only temporary immunity against selected HPV strains lasting 5-8 yrs, depending on vaccine. She says a full 15 years of immunity coverage is needed to prevent cervical cancer.  There is no long term data to show prevention of cervical cancer.  However, computer modeling projects that HPV vaccine programs reduces cervical cancer rates to 9-14 per 100,000.  PAP Smear Cytology screening programs in the US have already reduced cervical cancer rates to 8 per 100,000, and in Dr Harper’s opinion, HPV vaccine is unlikely to reduce this rate any further.

Video filmed at the American Association for the Advancement of Science Meeting in Washington, D.C., on February 18, 2011, Dr. Stan Maloy talks with Diane Harper, M.D., M.P.H,

The unethical and sleazy techniques used by vaccine makers Merck and GSK  to push their agenda for mandatory vaccination is described by Sara Abiola, JD, PhD and Michelle M. Mello, JD, PhD in their 2012 article. (2)  This is criminal behavior.

Merck promoted school-entry mandate legislation by serving as an information resource, lobbying legislators, drafting legislation, mobilizing female legislators and physician organizations, conducting consumer marketing campaigns, and filling gaps in access to the vaccine. Legislators relied heavily on Merck for scientific information. Most stakeholders found lobbying by vaccine manufacturers acceptable in principle, but perceived that Merck had acted too aggressively and nontransparently in this case. (2)

Adverse Effects of HPV Vaccine – Premature Ovarian Failure

The American College of Pediatricians has expressed opposition to mandatory HPV vaccination in this statement: “The College is opposed to any legislation which requires HPV vaccination for school attendance.”  The American College of Pediatricians has issued a warning statement about POV (Premature Ovarian Failure) caused by HPV vaccines. (5,6)(22,23)

See: Ovarian Failure After HPV Vaccine  by Scott S. Field, MD January 2016. (76-81)

HPV Vaccine Litigation is currently underway in the US for POV (Premature Ovarian Failure) and POTS (postural orthostatic hypothension) (76-81).

CNS Demyelinating Disease – Devastating Adverse Effect of HPV Vaccination

Perhaps the most devastating adverse effect of HPV Vaccination is demyelinating CNS disease in teenage boys and girls after HPV vaccination, transforming previously active healthy teenagers into quadriplagics on ventilators. Many such case reports can be found in the medical literature.(45-60)

Personal accounts of this devastating outcome can be found online reported by family members.

Other serious adverse effects include cerebral vasculitis and neurological disease.(11)

Onset of multiple sclerosis (MS) after HPV vaccination has have been reported. MS is an autoimmune neurological condition.(29)

Severe somatoform and dysautonomic syndromes after HPV vaccination has been reported in Italy (30) and Japan(44).

In Sweden, cluster analysis shows complex regional pain syndrome (CRPS), postural orthostatic tachycardia syndrome (POTS), and chronic fatigue syndrome (CFS) after human papillomavirus (HPV) vaccines.

Dr Poddighe  wrote in Immunol Res. 2014, these types of vaccine reactions are:

” autoimmune/inflammatory syndromes induced by vaccine adjuvants (ASIA)“ (33)

Documentary on the HPV Vaccine: Manufactured Crisis by The Alliance for Natural Health

Watch This HPV Documentary: Sacrificial Virgins is a documentary series in three parts written and narrated by Joan Shenton and directed by Andi Reiss. It is a co-production between Meditel Productions and Yellow Entertainment. Below is the 3-part series.

Danish documentary on HPV Vaccine Injured Young Girls in Denmark:

TV2 Denmark Documentary on HPV Vaccine Shows Lives of Young Women Ruined.

TV2 one of Denmark’s national television stations aired a documentary on Thursday, March 26, 2015, on HPV vaccines entitled, The Vaccinated Girls – Sick and Betrayed. It focused on the condition of 3 girls suffering from serious new medical conditions after being vaccinated against HPV with Gardasil.

Watch more videos documenting HPV Vaccine Injury.  12 year old Mia Blesky paralyzed after HPV vaccine: watch videos of Mia Blesky.

10% Of Girls Vaccinated Visit the ER Within 42 days

An 8 year Canadian study of HPV adverse events in 195,270 females receiving 528,913 doses of HPV vaccine reveals that 10% of girls vaccinated visited the ER within 42 days. (41)

See Liu, Xianfang C., et al. “Adverse events following HPV vaccination, Alberta 2006–2014.” Vaccine 34.15 (2016): 1800-1805.

Houston, We Have a Problem:Increasing Cervical Cancer Rates

Rather than decreasing Cervical Cancer rates, Countries with high HPV Vaccine coverage shows INCREASING cervical Cancer rates

2019:  PARADOXICAL EFFECT OF ANTI-HPV VACCINE GARDASIL ON CERVICAL CANCER RATE  Jan 2019 by Dr G Delépine, oncologist, surgeon, writes:

“In all countries that achieved high HPV vaccination coverage, official cancer registries show an increase in the incidence of invasive cervical cancer. ” Endquote Dr Delépine. (63)

Joseph Mercola MD: Cervical Cancer Rates Rising Despite HPV Vaccine 3/18/2023

What is the reason for this increase in cervical cancer rates in spite of the HPV Vaccine? The HPV 9 vaccine only includes nine strains of HPV virus. However, there are over 100 strains of HPV virus, and many of the non-covered strains (or genotypes)  are precancerous as well. Taking the vaccine covers the included 9 strains, which then “unmasks” all the other HPV strains not included in the vaccine. This is what is causing cervical cancer rates to increase. Referring to data come from the Costa Rica HPV Vaccine Trial, Dr Mercola writes:

After a follow-up of 11 years, among vaccinated women, there was an excess of precancerous cervical lesions caused by genotypes [strains] not included in the vaccine, resulting in negative vaccine efficacy for those HPV variants…The results are likely the first evidence to date of ‘clinical unmasking’ with HPV vaccination, meaning that protection against the strains covered by the vaccine leaves women more prone to attack from other carcinogenic HPV variants. (82)

Despite HPV Vaccine, Cervical Cancer Rates Keep Rising
Published on March 22, 2023 By Joseph Mercola 3/18/2023

In 2006, the first HPV vaccine, Gardasil, was licensed; Now, almost 17 years after the vaccine was introduced, there is a “troubling spike” in cervical cancer rates,[5] despite vaccination rates as high as 80 percent[6] (although rates vary widely between gender and ethnic groups.

As reported in the December 2022 issue of the International Journal of Gynecological Cancer:[8]

“When examining the trends over time, there has been an annual increase in distant stage cervical cancer at a rate of 1.3 percent per year. ..The largest increase is seen in cervical adenocarcinoma with an average annual percent change of 2.9 percent.”

when looking at HPV-related cancers in general, without regard for strain, rates have steadily increased since the vaccine’s introduction. As reported by the Kaiser Family Foundation (KFF) in July 2021,[11]

“HPV-related cancers have increased significantly in the past 15 years[12] — in 2015, 43,000 people developed an HPV-related cancer compared to 30,000 in 1999.”

The data come from the Costa Rica HPV Vaccine Trial, [16] which involved more than 10,000 women aged 18-25 years. The HPV vaccine used in the trial was Cervarix, from GlaxoSmith Kline. It covers the two leading causes of cervical cancer, HPV 16 and 18, and provides partial protection against three other genotypes.
After a follow-up of 11 years, among vaccinated women, there was an excess of precancerous cervical lesions caused by genotypes not included in the vaccine, resulting in negative vaccine efficacy for those HPV variants

The results are likely the first evidence to date of ‘clinical unmasking’ with HPV vaccination, meaning that protection against the strains covered by the vaccine leaves women more prone to attack from other carcinogenic HPV variants.(82)

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Dr. Nathan Riley Discusses HPV Vaccine Feb. 2024

Dr Nathan Riley says the risks of adverse effects from the HPV vaccine far exceeds the minsicule risk of getting cervical cancer, writing:

The risk of adverse effects from the HPV vaccine, quite frankly, according to Nathan, far exceeds the chances of getting cervical cancer… Most people don’t develop cervical cancer, even if they have HPV that hangs around for a while. HPV stands for Human PapillomaVirus. If you were to screen every single person, over 90% of people have been exposed to this but not over 90% are dying of cervical cancer…Most people don’t develop cervical cancer, even if they have HPV that hangs around for a while…Cervical cancer accounts for about 0.8% of all cancer deaths. We’re talking about a lifetime risk of probably 1 in 1 million…the risk of a severe adverse reaction from the vaccine is higher than your risk of dying from cervical cancer. (84)

Reference: What You Need to Know About The HPV Vaccine  with Nathan Riley, MD, is a board-certified OB-GYN and fellow of ACOG . February 5, 2024 By Hilda Labrada Gore/ Weston Price (84)

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Nov 2019:  OPINION: HPV vaccine incentive payments need to stop. Josh Mazur Guest Contributor Eye on Anapolis | November 04, 2019

Megan Heimer January 3, 2016  The HPV Vaccine: What You Need to Know About the Dumbest Vaccine Ever

2/7/18: FAKE NEWS ? – Study: HPV vaccine highly-effective at preventing cancers
Rae Daniel Feb 6, 2018  New study from Finland reported as showing HPV Vaccine effective at reducing cervical cancer rates.  In actuality, the Finnish study shows reduction in HPV rates, not in cervical cancer rates.(38-40)  No long term study has shown reduction in cervical cancer rates from HPV vaccination.(42)

1/2017 : Leslie, Douglas L., et al. “Temporal association of certain neuropsychiatric Disorders Following Vaccination of children and adolescents: a Pilot case–control study.” Frontiers in psychiatry 8 (2017): 3.

April 2018: Government Court Concedes Girl Killed By HPV Vaccine

Click Here for pdf of court ruling Christina Tarsell HPV Vaccine Special Master final Ruling 2017

2018: Aluminum in Vaccines as Cause of Immune Activation in the Brain.  International scientists have found autism’s cause. What will Americans do? BY J.B. HANDLEY April 2, 2018 “there’s an ongoing, permanent immune-system activation in the brains of autistic people.” HPV Vaccine contains aluminum adjuvants.

 

Buy the  Book on Amazon , The HPV Vaccine On Trial: Seeking Justice for a Generation Betrayed by Mary Holland

The HPV Vaccine On Trial: Seeking Justice for a Generation Betrayed Paperback – October 2, 2018 by Mary Holland (Author), Kim Mack Rosenberg (Author). Left Image: Book cover image courtesy of Amazon and Mary Holland.

Jeffrey Dach MD
7450 Griffin Road Suite 190
Davie, Florida 33314
954-792-4663

Articles with Related Interest

The Failure of Global Polio Eradication

Which is Greater Threat, Measles or measles Vaccine ?

Links and References

Header Image Courtesy of  Patriots and Paulies.

1) Harper, Diane M., and Leslie R. DeMars. “HPV vaccines–a review of the first decade.” Gynecologic oncology 146.1 (2017): 196-204.

Three dose efficacy preventing CIN 2 or worse by any HPV type is about 62% for both Cervarix and Gardsail9; the three dose efficacy preventing CIN 3 or worse by any HPV type is 93% for Cervarix and 43% for Gardasil, with no data for Gardasil9. All three vaccines lead to reduced numbers of colposcopies and excisional cervical therapies. Head to head trials indicate that Cervarix has superior immunogenicity compared to Gardasil for T-cell and B-cell functions for both HPV 16 and 18; there are no data for Gardasil9’s comparable immunogenicity. The immunogenicity data for HPV 18/45 induced by Gardasil and Gardasil9 indicates that long term surveillance for HPV 18/45 disease breakthrough must be in place.

Diane Medved Harper is a professor and chair of the department of Family and Geriatric Medicine at the University of Louisville.[3]

(2) Am J Public Health. 2012 May; 102(5): 893–898.
Pharmaceutical Companies’ Role in State Vaccination Policymaking: The Case of Human Papillomavirus Vaccination  Michelle M. Mello, JD, PhD,corresponding author Sara Abiola, JD, PhD, and James Colgrove, PhD

Objectives. We sought to investigate roles that Merck & Co Inc played in state human papillomavirus (HPV) immunization policymaking, to elicit key stakeholders’ perceptions of the appropriateness of these activities, and to explore implications for relationships between health policymakers and industry.

Methods. We used a series of state case studies combining data from key informant interviews with analysis of media reports and archival materials. We interviewed 73 key informants in 6 states that were actively engaged in HPV vaccine policy deliberations.

Results. Merck promoted school-entry mandate legislation by serving as an information resource, lobbying legislators, drafting legislation, mobilizing female legislators and physician organizations, conducting consumer marketing campaigns, and filling gaps in access to the vaccine. Legislators relied heavily on Merck for scientific information. Most stakeholders found lobbying by vaccine manufacturers acceptable in principle, but perceived that Merck had acted too aggressively and nontransparently in this case.

Conclusions. Although policymakers acknowledge the utility of manufacturers’ involvement in vaccination policymaking, industry lobbying that is overly aggressive, not fully transparent, or not divorced from financial contributions to lawmakers risks undermining the prospects for legislation to foster uptake of new vaccines.

In June 2006, the Food and Drug Administration approved the first vaccine against human papillomavirus (HPV), the sexually transmitted virus implicated in three quarters of all cases of cervical cancer. Gardasil, produced by Merck & Co Inc, was licensed for vaccination of females aged 9 to 26 years for the prevention of cervical cancer and genital warts.1 The same month, the Advisory Committee on Immunization Practices (ACIP) of the Centers for Disease Control and Prevention recommended routine vaccination of girls aged 11 to 12 years, with catch-up vaccination of females aged 13 to 26 years.2 A remarkable burst of legislative activity followed. Within a year, legislation relating to the vaccine was introduced in 41 states and the District of Columbia, including bills in 24 states that would mandate HPV vaccination for 6th-grade girls.3

Interest in the political forces behind HPV legislation remains high.4 Following media reports that Merck was heavily involved in promoting school-entry mandates, questions arose about the extent and appropriateness of industry involvement in vaccine policy. The presidential candidacy of Texas Governor Rick Perry recently prompted a new round of public and media scrutiny of the issue after opponent Representative Michele Bachmann accused the governor of ordering girls to receive the HPV vaccination because of his financial and political ties to Merck.5 We aimed to investigate these industry roles and elicit key stakeholders’ perceptions of their appropriateness and effects on policy outcomes.

3) Letters to the Editor  Does the HPV Vaccine Prevent Cervical Cancer?
ln reply: Existing HPV vaccines provide protection against high-risk HPV types that are known to cause cervical dysplasia, which leads to cervical cancer. The Centers for Disease Control and Prevention’s Advisory Committee on Immunization Practices recommends routine HPV vaccination at 11 to 12 years of age1 based on randomized controlled trials that demonstrate effective prevention against precancerous cervical lesions (cervical intraepithelial neoplasia 2 and 3).2,3 Because invasive cervical cancer is rare in the United States, studies have not yet established an association between HPV vaccination and a lower incidence of cervical cancer. However, the intent of HPV vaccination is ultimately to prevent cervical cancer.
KENNETH W. LIN, MD, MPH  Associate Deputy Editor for AFP Online

3) Tomljenovic, L., J. P. Spinosa, and C. A. Shaw. “Human papillomavirus (HPV) vaccines as an option for preventing cervical malignancies:(how) effective and safe?.” Current pharmaceutical design 19.8 (2013): 1466.Human papillomavirus HPV vaccines for preventing cervical malignancies how effective and safe Tomljenovic Spinosa Shaw Current pharm des 2013

We carried out a systematic review of HPV vaccine pre- and post-licensure trials to assess the evidence of their effectiveness and safety. We find that HPV vaccine clinical trials design, and data interpretation of both efficacy and safety outcomes, were largely inadequate. Additionally, we note evidence of selective reporting of results from clinical trials (i.e., exclusion of vaccine efficacy figures related to study subgroups in which efficacy might be lower or even negative from peer-reviewed publications). Given this, the widespread optimism regarding HPV vaccines long-term benefits appears to rest on a number of unproven assumptions (or such which are at odd with factual evidence) and significant misinterpretation of available data. For example, the claim that HPV vaccination will result in approximately 70% reduction of cervical cancers is made despite the fact that the clinical trials data have not demonstrated to date that the vaccines have actually prevented a single case of cervical cancer (let alone cervical cancer death), nor that the current overly optimistic surrogate marker-based extrapolations are justified. Likewise, the notion that HPV vaccines have an impressive safety profile is only supported by highly flawed design of safety trials and is contrary to accumulating evidence from vaccine safety surveillance databases and case reports which continue to link HPV vaccination to serious adverse outcomes (including death and permanent disabilities). We thus conclude that further reduction of cervical cancers might be best achieved by optimizing cervical screening (which carries no such risks) and targeting other factors of the disease rather than by the reliance on vaccines with questionable efficacy and safety profiles.

4)  Megan Heimer January 3, 2016  The HPV Vaccine: What You Need to Know About the Dumbest Vaccine Ever

Ovarian Failure

5) Colafrancesco, Serena, et al. “Human papilloma virus vaccine and primary ovarian failure: another facet of the autoimmune/inflammatory syndrome induced by adjuvants.” American Journal of Reproductive Immunology 70.4 (2013): 309-316.
PROBLEM:Post-vaccination autoimmune phenomena are a major facet of the autoimmune/inflammatory syndrome induced by adjuvants (ASIA) and different vaccines, including HPV, have been identified as possible causes.
METHOD OF STUDY:The medical history of three young women who presented with secondary amenorrhea following HPV vaccination was collected. Data regarding type of vaccine, number of vaccination, personal, clinical and serological features, as well as response to treatments were analyzed.
RESULTS:All three patients developed secondary amenorrhea following HPV vaccinations, which did not resolve upon treatment with hormone replacement therapies. In all three cases sexual development was normal and genetic screen revealed no pertinent abnormalities (i.e., Turner’s syndrome, Fragile X test were all negative). Serological evaluations showed low levels of estradiol and increased FSH and LH and in two cases, specific auto-antibodies were detected (antiovarian and anti thyroid), suggesting that the HPV vaccine triggered an autoimmune response. Pelvic ultrasound did not reveal any abnormalities in any of the three cases. All three patients experienced a range of common non-specific post-vaccine symptoms including nausea, headache, sleep disturbances, arthralgia and a range of cognitive and psychiatric disturbances. According to these clinical features, a diagnosis of primary ovarian failure (POF) was determined which also fulfilled the required criteria for the ASIA syndrome.
CONCLUSION:We documented here the evidence of the potential of the HPV vaccine to trigger a life-disabling autoimmune condition. The increasing number of similar reports of post HPV vaccine-linked autoimmunity and the uncertainty of long-term clinical benefits of HPV vaccination are a matter of public health that warrants further rigorous inquiry.

6) Little, Deirdre Therese, and Harvey Rodrick Grenville Ward. “Adolescent premature ovarian insufficiency following human papillomavirus vaccination: a case series seen in general practice.” Journal of investigative medicine high impact case reports 2.4 (2014): 2324709614556129.
Three young women who developed premature ovarian insufficiency following quadrivalent human papillomavirus (HPV) vaccination presented to a general practitioner in rural New South Wales, Australia. The unrelated girls were aged 16, 16, and 18 years at diagnosis. Each had received HPV vaccinations prior to the onset of ovarian decline. Vaccinations had been administered in different regions of the state of New South Wales and the 3 girls lived in different towns in that state. Each had been prescribed the oral contraceptive pill to treat menstrual cycle abnormalities prior to investigation and diagnosis. Vaccine research does not present an ovary histology report of tested rats but does present a testicular histology report. Enduring ovarian capacity and duration of function following vaccination is unresearched in preclinical studies, clinical and postlicensure studies. Postmarketing surveillance does not accurately represent diagnoses in adverse event notifications and can neither represent unnotified cases nor compare incident statistics with vaccine course administration rates. The potential significance of a case series of adolescents with idiopathic premature ovarian insufficiency following HPV vaccination presenting to a general practice warrants further research. Preservation of reproductive health is a primary concern in the recipient target group. Since this group includes all prepubertal and pubertal young women, demonstration of ongoing, uncompromised safety for the ovary is urgently required. This matter needs to be resolved for the purposes of population health and public vaccine confidence.

This second case series of adolescent POI/POF increases evidence suggesting that the hypothesis of an association between HPV vaccine and premature ovarian demise needs to be tested.

7) Tomljenovic, Lucija, et al. “HPV vaccines and cancer prevention, science versus activism.” Infectious Agents and Cancer 8.1 (2013): 6.
The rationale behind current worldwide human papilloma virus (HPV) vaccination programs starts from two basic premises, 1) that HPV vaccines will prevent cervical cancers and save lives and, 2) have no risk of serious side effects. Therefore, efforts should be made to get as many pre-adolescent girls vaccinated in order to decrease the burden of cervical cancer. Careful analysis of HPV vaccine pre- and post-licensure data shows however that both of these premises are at odds with factual evidence and are largely derived from significant misinterpretation of available data.

8) Nicol AF, Andrade CV, Russomano FB, Rodrigues LLS, Oliveira NS, Provance DW. HPV vaccines: a controversial issue? Brazilian Journal of Medical and Biological Research. 2016;49(5):e5060. doi:10.1590/1414-431X20155060.\

Controversy still exists over whether the benefits of the available HPV vaccines outweigh the risks and this has suppressed uptake of the HPV vaccines in comparison to other vaccines. Concerns about HPV vaccine safety have led some physicians, healthcare officials and parents to withhold the recommended vaccination from the target population. The most common reason for not administering the prophylactic HPV vaccines are concerns over adverse effects. The aim of this review is the assessment of peer-reviewed scientific data related to measurable outcomes from the use of HPV vaccines throughout the world with focused attention on the potential adverse effects. We found that the majority of studies continue to suggest a positive risk-benefit from vaccination against HPV, with minimal documented adverse effects, which is consistent with other vaccines. However, much of the published scientific data regarding the safety of HPV vaccines appears to originate from within the financially competitive HPV vaccine market. We advocate a more independent monitoring system for vaccine immunogenicity and adverse effects to address potential conflicts of interest with regular systematic literature reviews by qualified individuals to vigilantly assess and communicate adverse effects associated with HPV vaccination. Finally, our evaluation suggests that an expanded use of HPV vaccine into more diverse populations, particularly those living in low-resource settings, would provide numerous health and social benefits.

Since the quadrivalent HPV vaccine was approved by the FDA in the USA in June 2006, it will take at least another 15-20 years before the long-term efficacy of these vaccines becomes evident. In December 2014, the FDA approved the so-called HPV9 Gardasil¯ vaccine that includes direct protection against HPV types 31, 33, 45, 52 and 58 in addition to the HPV types 6, 11, 16 and 18 of the quadrivalent vaccine.

While the reduction in the occurrence of genital warts conferred by the HPV types present in the vaccines strongly suggests an ultimately lower incidence of HPV-positive cancers, the time period since the initial vaccinations has not been sufficient to determine the absolute reduction in cervical cancer, the major benefit expected.\\\

We also strongly believe that a regular systematic review of the literature by qualified individuals with no financial interests should be conducted. In many instances, financial resources originate from parties within the competitive HPV vaccine market, which certainly have economic interests, causing major complications in interpreting the results and conclusions from the various studies.

9) Aşkın, Özge. “Anogenital HPV.” Fundamentals of Sexually Transmitted Infections. InTech, 2017.  Duration of efficacy is a key question when discussing the HPV vaccines. All three vaccines provide very high immunogenicity with antibody titers that are higher than the natural infections and remain high enough to prevent new infections. Booster doses’ necessity is still unknown. Up to now, it has been shown that the duration of vaccines may last 5–9 years. But more studies are needed about these important issues [35, 38].

The development of HPV vaccine is a milestone in the prevention of HPV-related infections and probably in the prevention of cervical cancer.

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Lucija Tomljenovic

10) Is There Objective Evidence that the Current HPV Vaccination Programs are not Justified?
Posted by Celeste McGovern on Mar 1, 2017 10:03:19 AM
In closing, Dr. Tomljenovic challenges her audience with a question: Is it ethical to put at risk of death or a disabling autoimmune disease at a pre-adolescent age for a vaccine that has not yet prevented a single case of cervical cancer, a disease that may develop 20-30 years after exposure to HPV, when the same can be prevented with regular PAP screening which carries no risks? Probably not.

Death after Quadrivalent Human Papillomavirus (HPV) Vaccination:Causal or Coincidental?

11)  Death after Quadrivalent Human Papillomavirus (HPV) Vaccination:Causal or Coincidental?  Tomljenovic L, Shaw CA (2012) Death after Quadrivalent Human Papillomavirus (HPV) Vaccination: Causal or Coincidental? Pharmaceut Reg Affairs S12:001.

Abstract Background: The proper understanding of a true risk from vaccines is crucial for avoiding unnecessary adverse reactions (ADRs). However, to this date no solid tests or criteria have been established to determine whether adverse events are causally linked to vaccinations. Objectives: This research was carried out to determine whether or not some serious autoimmune and neurological ADRs following HPV vaccination are causal or merely coincidental and to validate a biomarker-based immunohistochemical (IHC) protocol for assessing causality in case of vaccination-suspected serious adverse neurological outcomes. Methods: Post-mortem brain tissue specimens from two young women who suffered from cerebral vasculitistype symptoms following vaccination with the HPV vaccine Gardasil were analysed by IHC for various immunoinflammatory markers. Brain sections were also stained for antibodies recognizing HPV-16L1 and HPV-18L1 antigen which are present in Gardasil. Results: In both cases, the autopsy revealed no anatomical, microbiological nor toxicological findings that might have explained the death of the individuals. In contrast, our IHC analysis showed evidence of an autoimmune vasculitis potentially triggered by the cross-reactive HPV-16L1 antibodies binding to the wall of cerebral blood vessels in all examined brain samples. We also detected the presence of HPV-16L1 particles within the cerebral vasculature with some HPV-16L1 particles adhering to the blood vessel walls. HPV-18L1 antibodies did not bind to cerebral blood vessels nor any other neural tissues. IHC also showed increased T-cell signalling and marked activation of the classical antibody-dependent complement pathway in cerebral vascular tissues from both cases. This pattern of complement activation in the absence of an active brain infection indicates an abnormal triggering of the immune response in which the immune attack is directed towards self-tissue. Conclusions: Our study suggests that HPV vaccines containing HPV-16L1 antigens pose an inherent risk for triggering potentially fatal autoimmune vasculopathies. Practice implications: Cerebral vasculitis is a serious disease which typically results in fatal outcomes when undiagnosed and left untreated. The fact that many of the symptoms reported to vaccine safety surveillance databases following HPV vaccination are indicative of cerebral vasculitis, but are unrecognized as such (i.e., intense persistent migraines, syncope, seizures, tremors and tingling, myalgia, locomotor abnormalities, psychotic symptoms and cognitive deficits), is a serious concern in light of the present findings. It thus appears that in some cases vaccination may be the triggering factor of fatal autoimmune/neurological events. Physicians should be aware of this association.

13) video  <iframe width=”560″ height=”315″ src=”https://www.youtube.com/embed/XBr1knRaRCc” frameborder=”0″ allow=”autoplay; encrypted-media” allowfullscreen></iframe>

Lucija Tomljenovic, PhD Session 7: 4th International Symposium on Vaccines in Leipzig, Germany April, 2016

Diane Harper researcher
90% of HPV cleared by immune system
HPV trials only 3 years in duration

efficacy of vaccine too short to prevent cervical cancer

Manitoba vaccine efficacy on preventing cervical dysplasia and in-situ CA -ineffective

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CArcinoma in situ less in non-vaccinated over 3 years observation.

14) Mahmud, Salaheddin M., et al. “Effectiveness of the quadrivalent human papillomavirus vaccine against cervical dysplasia in Manitoba, Canada.” Journal of Clinical Oncology 32.5 (2014): 438-443.

The median length of follow-up after enrollment was 3.1 years (range, 0.1 to 5.4). Overall, the 3-year cumulative probability of LSIL (3.7%) and HSIL (2.6%) was slightly higher in the nonvaccinated cohort compared with the vaccinated cohort (3.3% and 2.3%, respectively), whereas that of ASCUS was similar (2.8%). No invasive cancers were detected in either cohort, but 12 vaccinated females (0.3%) and 22 nonvaccinated females (0.2%) had CIS during follow-up.

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Pro-Vaccine Article

15)  HPV Vaccine Controversy Ethics Economics Equality By Tanya Donahou
HPV Vaccine Controversy: Ethics, Economics, and Equality By Tanya Donahou, MD/MPH candidate,  Boston University Schools of Medicine and Public Health, Class of 2013

Vaccine prevents CIN

16)  Herweijer, Eva, et al. “Quadrivalent HPV vaccine effectiveness against high‐grade cervical lesions by age at vaccination: A population‐based study.” International journal of cancer 138.12 (2016): 2867-2874.
In conclusion, we show effectiveness of opportunistic qHPV vaccination for preventing CIN2+ and CIN3+ lesions, with greater effectiveness observed in girls younger at vaccination initiation.

Reply to above

17) Forced-Vaccinations-For-the-Greater-Good-Tomljenovic  — By Lucija Tomljenovic, PhD

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18)  HPV (Gardasil) injury scandals worldwide, why is U.S. media silent? Parents beware.
BY J.B. HANDLEY December 7, 2016

19) Govt. Still Pushing HPV Vaccine on Kids a Decade after JW Exposed Deadly Side Effects   MARCH 09, 2017

How Effective Is the HPV Vaccine at Preventing Cancer? A Closer Look…

How Effective Is the HPV Vaccine at Preventing Cancer? A Closer Look…
By Jeanne Lenzer | November 23, 2011 12:51 pm

Unfortunately, while the two HPV vaccines on the market may decrease the serious illness and death from cervical cancer, no study has proved that at this point, since no study has been conducted long enough to observe the development of cervical cancer or cervical cancer deaths.

Conclusive studies with the most important, clinically relevant end points should precede wide uptake of any intervention. The data currently rely on surrogate end points (markers of possible cancer) and are simply not conclusive. So we can’t truly say how effective the vaccine is.

Wake Forest medical researcher Curt Furberg, a former FDA advisor and co-author of the textbook Fundamentals of Clinical Trials, told me, “Getting data from markers is a first step. But we have burned our fingers too many times with surrogate markers. You should try to determine the real health benefit. Everything will be up in the air until we have the answer to the question: Will it prevent cancer? And until we have that answer, we should limit its use to girls enrolled in studies of the vaccine.”

Here are some other reasons why the HPV vaccines may not be as effective as advertised:

Duration of Protection:

An important issue raised by Diane Harper, an HPV researcher, is how long the vaccine will remain effective. She says the antibody titers in women who receive the vaccine fall off over time—i.e., the vaccine loses effectiveness. “One third of women lose antibody titers and hence protection from HPV by 5 years,” and “at 8.5 years, 15 percent have lost all detectable antibody titers to HPV-16, which leaves them completely unprotected from HPV-16 and -18, the only two cancer-causing strains that Gardasil was supposed to protect against.”

Harper says because of the vaccine’s limited duration, it likely won’t decrease the cervical cancer rate significantly below where it is with the routine Pap screening currently in use, although it may postpone cancer until later in life. Booster shots could presumably extend the effectiveness of the vaccine, she says, but we don’t yet have data on that. (Harper has received funding from Merck and GlaxoSmithKline for research on their HPV vaccines.)

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20) Preventing Cervical Cancer Investigating costs, access, marketing, and effectiveness of vaccines By Donald W Light · Published 2017

While numerous studies that show the vaccines are cost-effective assume they prevent cancer, independent critics point out we don’t know and “the real impact of HPV vaccination on cervical cancer will not be observable for decades

Merck states that Gardasil 9 “does not eliminate the necessity for girls to undergo recommended cervical cancer screening later in life.
“The duration of immunity of Gardasil 9 has not been established” (MerckVaccines 2017).

To the extent that marketing lulls women into believing they are covered and no longer need routine screening, cancer rates could increase (Lenzer 2011).

Evidence that HPV vaccines prevent cancer is indirect because the latency period of fifteen to twenty years exceeds the time since use began.

We will not know for years how effectively HPV vaccines actually prevent cervical and related cancers or how the population of viral serotypes adapts.

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21) Gardasil Shocker: Japan Withdraws Support for HPV Vaccine by Sarah Updated: January 25, 2018

Primary Ovarian Failure after HPV Vaccine

22) American College of Pediatricians Sounds Alarm About HPV Vaccine (Gardasil) by Sarah Updated: January 25, 2018

23) Ovarian Failure After HPV Vaccine  Primary author: Scott S. Field, MD January 2016 The American College of Pediatricians

2. Little DT, and Ward HR. Adolescent premature ovarian insufficiency following human papillomavirus vaccination: a case series seen in general practice. J Inv Med High Imp Case Rep. 2014; doi: 10.1177/2324709614556129, pp 1-12.

3. Wise LD, Wolf JJ, Kaplanski CV, Pauley CJ, Ledwith BJ. Lack of effects on fertility and developemental toxicity of a quadrivalent HPV vaccine in Sprague-Dawley rats. Birth Defects Res B Dev. 2008; 83(6):561-572.

4. Segal L, Wilby OK, Willoughby CR, Veenstra S, Deschamps M. Evaluation of the intramuscular administration of CervarixTM vaccine on fertility, pre- and post-natal development in rats. Reprod Toxicol. 2011; 31:111-120.

5. Information available through http://wonder.cdc.gov/vaers.html.

6. http://www.cdc.gov/vaccines/pubs/pinkbook/downloads/appendices/B/excipient-table-2.pdf.

7. http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM111287.pdf, p.373.

8. Vichnin M, Bonanni P, Klein NP, Garland SM, Block SL, Kjaer SK, et. al. An overview of quadrivalent human papillomavirus vaccine safety – 2006 to 2015. Pediatr Inf Dis J. 2015; doi: 10.1097/INF.0000000000000793, pp 1-48.

9. http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM111287.pdf, p.394,396.

24)  Gardasil: Guarding or Gutting Our Youth? by Kelly Brogan MD

25)   Gardasil Vaccine: Spain Joins Growing List of Countries to File Criminal Complaints
includes France, India, Japan, and many more.

26)   Gardisal Vaccine FRANCE SAYS “NO” AS THEY BAN GARDASIL ADS
France says the award winning advertising campaign for Gardasil is false and misleading. The Sanevax Team wants to know – Where was the press coverage when this happened? Why did no one break the news to the public?

27) Colafrancesco S, Perricone C, Tomljenovic L, Shoenfeld Y. Human papilloma virus vaccine and primary ovarian failure: another facet of the autoimmune/inflammatory syndrome induced by adjuvants. Am J Reprod Immunol. 2013; 70:309-316.

28)  Ferris D, Samakoses R, Block S et al. 4-valent human papillomavirus (4vHPV) vaccine in preadolescents and adolescents after 10 years. Pediatrics 2017;140:e20163947. doi: 10.1542/peds.2016-3947

29) Hu Y, Tornes L, Lopez-Alberola R. Two cases of pediatric multiple sclerosis after human papillomavirus vaccination. Presented at: ACTRIMS Forum 2018; February 1-3, 2018; San Diego, CA. Abstract #P088

30) Palmieri, Beniamino, et al. “Severe somatoform and dysautonomic syndromes after HPV vaccination: case series and review of literature.” (2016). Severe somatoform and dysautonomic syndromes after HPV vaccination 2016 Palmieri Beniamino

31)   Chandler, Rebecca E., et al. “Current Safety Concerns with Human Papillomavirus Vaccine: A Cluster Analysis of Reports in VigiBase®.” Drug Safety 40.1 (2017): 81.

complex regional pain syndrome (CRPS), postural orthostatic tachycardia syndrome (POTS), and chronic fatigue syndrome (CFS)—have emerged with human papillomavirus (HPV) vaccines,

32)  Beppu, Hirokuni, et al. “Lessons learnt in Japan from adverse reactions to the HPV vaccine: a medical ethics perspective.” Indian journal of medical ethics 2.2 (2017): 82-88. Lessons learnt in Japan adverse reactions to HPV vaccine medical ethics Beppu Indian j med ethics 2017

33) Gentili, Marta, et al. “On the relationship between human papilloma virus vaccine and autoimmune diseases.” (2014). Relationship between human papilloma virus vaccine and autoimmune diseases Gentili Marta 2014

34) Immunol Res. 2014 Dec;60(2-3):236-46. A sudden onset of a pseudo-neurological syndrome after HPV-16/18 AS04-adjuvated vaccine: might it be an autoimmune/inflammatory syndrome induced by adjuvants (ASIA) presenting as a somatoform disorder? Poddighe D1, Castelli L, Marseglia GL, Bruni P.

In last centuries, vaccines reduced the incidence of several infectious diseases. In last decades, some vaccines aimed at preventing also some cancers, where viruses play a causative role. However, several adverse events have been described after vaccines, but a causal relationship has been established only in a minority of cases. Here, we describe a pseudo-neurological syndrome occurred shortly after the administration of the bivalent HPV vaccine. Some autoimmune disorders, including neurological demyelinating diseases, have been reported after HPV vaccines, but the patient showed no organic lesions. The patient was diagnosed as having a functional somatoform syndrome, which was supposed to be autoimmune/inflammatory syndrome induced by adjuvants (ASIA), seen the temporal link with vaccination and the presence of anti-phospholipid autoantibodies. Immunological mechanisms of vaccines-and of adjuvants-have not been completely elucidated yet, and although there is no evidence of statistical association with many post-vaccination events, a causal link with vaccine cannot be excluded in some individuals.

35) Segal, Yahel, and Yehuda Shoenfeld. “Vaccines-the good, the bad, and the unkown.” Intern Med 281.3 (2017): 313-5. Vaccines the good the bad and the unkown Segal Yahel Yehuda Shoenfeld Intern Med 2017

36) Watad, Abdulla, et al. “The autoimmune/inflammatory syndrome induced by adjuvants (ASIA)/Shoenfeld’s syndrome: descriptive analysis of 300 patients from the international ASIA syndrome registry.” Clinical rheumatology 37.2 (2018): 483-493.
The autoimmune/inflammatory syndrome induced by adjuvants (ASIA) is a recently identified condition in which the exposure to an adjuvant leads to an aberrant autoimmune response. We aimed to summarize the results obtained from the ASIA syndrome registry up to December 2016, in a descriptive analysis of 300 cases of ASIA syndrome, with a focus on the adjuvants, the clinical manifestations, and the relationship with other autoimmune diseases. A Web-based registry, based on a multicenter international study, collected clinical and laboratory data in a form of a questionnaire applied to patients with ASIA syndrome. Experts in the disease validated all cases independently. A comparison study regarding type of adjuvants and differences in clinical and laboratory findings was performed. Three hundred patients were analyzed. The mean age at disease onset was 37 years, and the mean duration of time latency between adjuvant stimuli and development of autoimmune conditions was 16.8 months, ranging between 3 days to 5 years. Arthralgia, myalgia, and chronic fatigue were the most frequently reported symptoms. Eighty-nine percent of patients were also diagnosed with another defined rheumatic/autoimmune condition. The most frequent autoimmune disease related to ASIA syndrome was undifferentiated connective tissue disease (UCTD). ASIA syndrome is associated with a high incidence of UCTD and positive anti-nuclear antibodies (ANA) test. Clinical and laboratory features differ from the type of adjuvant used. These findings may contribute to an increased awareness of ASIA syndrome and help physicians to identify patients at a greater risk of autoimmune diseases following the exposure to vaccines and other adjuvants. The ASIA syndrome registry provides a useful tool to systematize this rare condition.

37) The HPV Debacle: Suppressing Inconvenient Evidence By Vera Sharav

FAKE NEWS ?

38)  FAKE NEWS  – Study: HPV vaccine highly-effective at preventing cancers
Rae Daniel 5:24 PM, Feb 6, 2018

KANSAS CITY, Kan. — A new study has found that the HPV vaccine is highly-effective at preventing cancers in women.  The Human Papillomavirus is one that can cause cancer such as cervical and head and neck. “Frequently young people, young men and women, and that’ll be the most common HPV related cancer in the next few years in the U.S.,” Dr. Kevin Ault with the University of Kansas Health System.   A new preliminary report on the HPV vaccine came out in the International Journal of Cancer from Finland, one of the first countries that started using the HPV vaccine 15 years ago.

This is the study: No mention of the number of cases of cervical cancer in vaccinated group compared to placebo group in the article itself.

39) Gray, Penelope, et al. “Evaluation of HPV type‐replacement in unvaccinated and vaccinated adolescent females–Post‐hoc analysis of a community‐randomized clinical trial (II).” International Journal of Cancer (2018).
Efficacy of human papillomavirus (HPV) vaccines promises to control HPV infections. However, HPV vaccination program may lay bare an ecological niche for non-vaccine HPV types. We evaluated type-replacement by HPV type and vaccination strategy in a community-randomized trial executed in HPV vaccination naïve population. Thirty-three communities were randomized to gender-neutral vaccination with AS04-adjuvanted HPV16/18 vaccine (Arm A), HPV vaccination of girls and hepatitis B-virus (HBV) vaccination of boys (Arm B), and gender-neutral HBV vaccination (Arm C). Resident 1992-95 born boys (40,852) and girls (39,420) were invited. HPV typing of 11,396 cervicovaginal samples was performed by high throughput PCR. Prevalence ratios (PR) between arms and ranked order of HPV types, and odds ratio (OR) for having multiple HPV types in HPV16 or 18/45 positive individuals were calculated. 11,662 boys and 20,513 girls were vaccinated with 20-30% and 45-48% coverage, respectively. The ranked order of HPV types did not significantly differ between arms or birth cohorts. For the non-HPV vaccinated 1992-93 birth cohorts increased PR, between the gender-neutral intervention vs. control arms for HPV39 (PRA 1.84, 95% CI 1.12-3.02) and HPV51 (PRA 1.56, 95% CI 1.11-2.19) were observed. In the gender-neutral arm, increased clustering between HPV39 and the vaccine-covered HPV types 16 or 18/45 (ORA16=5.1, ORA18/45=11.4) was observed in the non-HPV vaccinated 1994-95 birth cohorts. Comparable clustering was seen between HPV51 and HPV16 or HPV18/45 (ORB16=4.7, ORB18/45=4.3), in the girls-only arm. In conclusion, definitively consistent post-vaccination patterns of HPV type-replacement were not observed. Future occurrence of HPV39 and HPV51 warrant investigation. This article is protected by copyright. All rights reserved.

40) Lehtinen, Matti, et al. “Impact of gender‐neutral or girls‐only vaccination against human papillomavirus—Results of a community‐randomized clinical trial (I).” International journal of cancer 142.5 (2018): 949-958.
Human papillomavirus (HPV) vaccine is efficacious but the real-life effectiveness of gender-neutral and girls-only vaccination strategies is unknown. We report a community-randomized trial on the protective effectiveness [(PE) = vaccine efficacy (VE) + herd effect (HE)] of the two strategies among females in virtually HPV vaccination naïve population. We randomized 33 Finnish communities into Arm A) gender-neutral vaccination with AS04-adjuvanted HPV16/18 vaccine (11 communities), Arm B) HPV vaccination of girls and hepatitis B-virus (HBV) vaccination of boys (11 communities) or Arm C) gender-neutral HBV vaccination (11 communities). All resident 39,420 females and 40,852 males born 1992-95 were invited in 2007-09. Virtually all (99%) 12- to 15-year-old participating males (11,662) and females (20,513) received three doses resulting in uniform 20-30% male and 50% female vaccination coverage by birth cohort. Four years later (2010-14) 11,396 cervicovaginal samples obtained from 18.5 year-old women were tested for HPV DNA, and prevalence of cervical HPV infections by trial arm and birth cohort was the main outcome measure. VEs against HPV16/18 varied between 89.2% and 95.2% across birth cohorts in arms A and B. The VEs against non-vaccine types consistent with cross-protection were highest in those born 1994-95 for HPV45 (VEA 82.8%; VEB 86.1%) and for HPV31 (VEA 77.6%, VEB 84.6%). The HEs in the non HPV-vaccinated were statistically significant in those born 1994-95 for HPV18 (HEA 51.0%; 95% CI 8.3-73.8, HEB 47.2%; 6.5-70.2) and for HPV31/33 in arm A (HEA 53.7%; 22.1-72.5). For HPV16 and 45 no significant herd effects were detected. PE estimates against HPV16/18 were similar by both strategies (PEA 58.1%; 45.1-69.4; PEB 55.7%; 42.9-66.6). PE estimates against HPV31/33 were higher by the gender-neutral vaccination (PEA 60.5%; 43.6-73.4; PEB 44.5%; 24.9-60.6). In conclusion, while gender-neutral strategy enhanced the effectiveness of HPV vaccination for cross-protected HPV types with low to moderate coverage, high coverage in males appears to be key to providing a substantial public health benefit also to unvaccinated females.

41)  Liu, Xianfang C., et al. “Adverse events following HPV vaccination, Alberta 2006–2014.” Vaccine 34.15 (2016): 1800-1805.
Results Over the period 195,270 females received 528,913 doses of HPV vaccine. Of those receiving at least one dose, 192 reported one or more AEFI events (198 AEFI events), i.e., 37.4/100,000 doses administered (95% CI 32.5–43.0). None were consistent with VTE. Of the women who received HPV vaccine 958 were hospitalized and 19,351 had an ED visit within 42 days of immunization. Four women who had an ED visit and hospitalization event were diagnosed with VTE. Three of these had other diagnoses known to be associated with VTE; the fourth woman had VTE among ED diagnoses but not among those for the hospitalization.

42)  Tomljenovic, Lucija, and Christopher A. Shaw. “Human papillomavirus (HPV) vaccine policy and evidence-based medicine: Are they at odds?.” (2011). Human papillomavirus HPV vaccine policy evidence based medicine Are they at odds Tomljenovic Lucija Christopher Shaw 2011

All drugs are associated with some risks of adverse reactions. Because vaccines represent a special category of drugs, generally given to healthy individuals, uncertain benefits mean that only a small level of risk for adverse reactions is acceptable. Furthermore, medical ethics demand that vaccination should be carried out with the participant’s full and informed consent. This necessitates an objective disclosure of the known or foreseeable vaccination benefits and risks. The way in which HPV vaccines are often promoted to women indicates that such disclosure is not always given from the basis of the best available knowledge. For example, while the world’s leading medical authorities state that HPV vaccines are an important cervical cancer prevention tool, clinical trials show no evidence that HPV vaccination can protect against cervical cancer. Similarly, contrary to claims that cervical cancer is the second most common cancer in women worldwide, existing data show that this only applies to developing countries. In the Western world cervical cancer is a rare disease with mortality rates that are several times lower than the rate of reported serious adverse reactions (including deaths) from HPV vaccination. Future vaccination policies should adhere more rigorously to evidence-based medicine and ethical guidelines for informed consent

Silencing Dissent

43)  How Silencing of Dissent in Science Impacts Woman. The Gardasil Story
Leonard F. Vernon. Advances in Sexual Medicine, 2017,7,179-204. How Silencing of Dissent in Science Impacts Woman The Gardasil Story Leonard F Vernon Advances 2017

Peripheral sympathetic nerve dysfunction

free pdf
44) Kinoshita, Tomomi, et al. “Peripheral sympathetic nerve dysfunction in adolescent Japanese girls following immunization with the human papillomavirus vaccine.” Internal Medicine 53.19 (2014): 2185-2200.  Peripheral sympathetic nerve dysfunction following immunization with human papillomavirus vaccine HPV Kinoshita Tomomi Int Med 2014

Encephalo-Myelitis – White Matter Demyelinating syndrome

45) DiMario Jr, Francis J., Mirna Hajjar, and Thomas Ciesielski. “A 16-year-old girl with bilateral visual loss and left hemiparesis following an immunization against human papilloma virus.” Journal of child neurology 25.3 (2010): 321-327.Bilateral visual loss and left hemiparesis following immunization human papilloma virus HPV DiMario J child neurology 2010

Cervical transverse myelitis

46) Fernández-Fournier, Mireya, et al. “Early cervical myelitis after human papilloma virus vaccination.” Neurology-Neuroimmunology Neuroinflammation 1.3 (2014): e31.

47)  Sekiguchi, Kenji, et al. “Two cases of acute disseminated encephalomyelitis following vaccination against human papilloma virus.” Internal Medicine 55.21 (2016): 3181-3184.

48) Bomprezzi, Roberto. “Acute disseminated encephalomyelitis following vaccination against human papilloma virus.” Neurology 74.10 (2010): 864-865.

49)  Wildemann, B., et al. “Acute disseminated encephalomyelitis following vaccination against human papilloma virus.” Neurology 72.24 (2009): 2132-2133.

50) Sutton, I., et al. “CNS demyelination and quadrivalent HPV vaccination.” Multiple Sclerosis 15 (2009): 116-119.  CNS demyelination and quadrivalent HPV vaccination Sutton Multiple Sclerosis 2009

60)  Chang, Jason, et al. “Demyelinating disease and polyvalent human papilloma virus vaccination.” J Neurol Neurosurg Psychiatry 82.11 (2011): 1296-1298.

61) R.E.G.R.E.T. Support Group was set up by parents of Irish teenage girls who have developed serious health problems after entering secondary school. These parents are certain that the HPV vaccine (Gardasil) is the cause of their daughters’ otherwise unexplained illness.

The primary goal of the parents in the group is to get help for their daughters who, like many girls around the world, have experienced “Reactions and Effects of Gardasil Resulting in Extreme Trauma” (R.E.G.R.E.T). Many are not receiving effective medical treatment and cannot attend school regularly due to the debilitating health conditions they still suffer from.

61) Medwatcher Japan international symposium: ”The Current Status of Worldwide Injuries from the HPV Vaccine”. Tokyo on March 24, 2018,  340 participants. Video of presentations.

62) The Truth About The HPV Vaccine 10/7/2018 jefferey jaxen

63)  PARADOXICAL EFFECT OF ANTI-HPV VACCINE GARDASIL ON CERVICAL CANCER RATE
31 janvier 2019 by Dr G Delépine, oncologist, surgeon

In all countries that achieved high HPV vaccination coverage, official cancer registries show an increase in the incidence of invasive cervical cancer.

64)  Family Found to Have Met Burden of Proof that Gardasil Caused Daughter’s Death Roopal Luhana Feb 20, 2019 New York Legal examiner

64)  The HPV vaccine is on trial as anti-vaxxers mobilize against effective cancer prevention July 24, 2019, 4:38 AM EDT
By Tara C. Smith, professor of epidemiology at Kent State University  (Tara Smith is a Pro-Vaccine Activist)

65) October 21, 2017 By Tara C. Smith, Ph.D. Who Should Get the HPV Vaccine?

66)  How Effective Is the HPV Vaccine at Preventing Cancer? A Closer Look… By Jeanne Lenzer | November 23, 2011 12:51 pm

67)  J Pediatr Pharmacol Ther. 2008 Jan-Mar; 13(1): 47–50.
Human Papillomavirus Vaccination: A Case for Mandatory Immunization?  Kristin Klein, PharmD, Sherry Luedtke, PharmD, and the Advocacy Committee of the Pediatric Pharmacy Advocacy Group Pediatric Pharmacy Advocacy Group, 7975 Stage Hills Blvd Ste 6, Memphis, TN 38133, Matt Helms.  (This is a Pharma Funded Advocacy Group)

 

68) DeLong, Gayle. “A lowered probability of pregnancy in females in the USA aged 25–29 who received a human papillomavirus vaccine injection.” Journal of Toxicology and Environmental Health, Part A 81.14 (2018): 661-674.

Birth rates in the United States have recently fallen. Birth rates per 1000 females aged 25-29 fell from 118 in 2007 to 105 in 2015. One factor may involve the vaccination against the human papillomavirus (HPV). Shortly after the vaccine was licensed, several reports of recipients experiencing primary ovarian failure emerged. This study analyzed information gathered in National Health and Nutrition Examination Survey, which represented 8 million 25-to-29-year-old women residing in the United States between 2007 and 2014. Approximately 60% of women who did not receive the HPV vaccine had been pregnant at least once, whereas only 35% of women who were exposed to the vaccine had conceived. For married women, 75% who did not receive the shot were found to conceive, while only 50% who received the vaccine had ever been pregnant. Using logistic regression to analyze the data, the probability of having been pregnant was estimated for females who received an HPV vaccine compared with females who did not receive the shot. Results suggest that females who received the HPV shot were less likely to have ever been pregnant than women in the same age group who did not receive the shot. If 100% of females in this study had received the HPV vaccine, data suggest the number of women having ever conceived would have fallen by 2 million. Further study into the influence of HPV vaccine on fertility is thus warranted.

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69)  Family Found to Have Met Burden of Proof that Gardasil Caused Daughter’s Death Roopal Luhana Feb 20, 2019 New York Legal examiner

70)  https://www.nbcnews.com/think/opinion/hpv-vaccine-trial-anti-vaxxers-mobilize-against-effective-cancer-prevention-ncna1033161
The HPV vaccine is on trial as anti-vaxxers mobilize against effective cancer prevention July 24, 2019, 4:38 AM EDT
By Tara C. Smith, professor of epidemiology at Kent State University

71) https://www.self.com/story/who-should-get-the-hpv-vaccine
October 21, 2017|By Tara C. Smith, Ph.D. Who Should Get the HPV Vaccine?

72)  How Effective Is the HPV Vaccine at Preventing Cancer? A Closer Look…By Jeanne Lenzer | November 23, 2011 12:51 pm

73) J Pediatr Pharmacol Ther. 2008 Jan-Mar; 13(1): 47–50.
Human Papillomavirus Vaccination: A Case for Mandatory Immunization?  Kristin Klein, PharmD, Sherry Luedtke, PharmD, and the Advocacy Committee of the Pediatric Pharmacy Advocacy Group  Pediatric Pharmacy Advocacy Group, 7975 Stage Hills Blvd Ste 6, Memphis, TN 38133, Matt Helms

74) Guo F, Cofie LE, Berenson AB. Cervical Cancer Incidence in Young U.S. Females After Human Papillomavirus Vaccine Introduction. Am J Prev Med. 2018 Aug;55(2):197-204.

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2024 Lawsuits

75) Gardasil HPV Vaccine Lawsuit The Lanier Law Firm. Legally Reviewed By: Michelle Greene Attorney | Pharmaceutical Liability February 2, 2024

injuries suffered from HPV vaccine:
the vaccine is not very effective , the vaccine causes auto immune injuries: POTS, premature primary ovarian failure (infertility).

2024 Gardasil Lawsuit Updates
February 2, 2023: There are currently 132 cases in the Gardasil MDL, with more being filed every month. The first bellwether trials will focus on premature ovarian failure and postural orthostatic tachycardia syndrome. The first trial may occur in 2025.

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76) Gardasil Lawsuit Miller and Zois Law Firm

POI (Premature Ovarian Insufficiency): POI is a medical condition in which a woman’s ovaries stop functioning normally before the age of 40. It is characterized by a decrease in ovarian function, leading to irregular or absent menstrual periods and infertility. POI can be caused by various factors, including genetics, autoimmune diseases, and certain medical treatments. These are the lawsuits our attorneys are most interested in handling.
POTS (Postural Orthostatic Tachycardia Syndrome): POTS is a medical condition characterized by an abnormal increase in heart rate when transitioning from a lying or sitting position to a standing position. This condition can lead to symptoms like dizziness, lightheadedness, fatigue, and sometimes fainting.

Other adverse effects of HPV Vaccine:
Guillain–Barré syndrome Orthostatic Intolerance
Small Fiber Neuropathy Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
Systemic Lupus Erythematosus Multiple Sclerosis
Autoimmune Pancreatitis Autoimmune Hepatitis
Fibromyalgia Premature Ovarian Failure
Chronic Regional Pain Syndrome

77) Little, Deirdre Therese, and Harvey Rodrick Grenville Ward. “Premature ovarian failure 3 years after menarche in a 16-year-old girl following human papillomavirus vaccination.” Case Reports 2012 (2012): bcr2012006879.

78) Tatang, Collins, et al. “Human papillomavirus vaccination and premature ovarian failure: a disproportionality analysis using the vaccine adverse event reporting system.” Drugs-Real World Outcomes (2022): 1-12.
Our study suggests the presence of a potential safety signal of POF associated with HPV vaccination,

79) Gong, Li, et al. “Human papillomavirus vaccine-associated premature ovarian insufficiency and related adverse events: data mining of Vaccine Adverse Event Reporting System.” Scientific reports 10.1 (2020): 10762.

We detected disproportionate reports of premature ovarian insufficiency (POI) and related events, including amenorrhea, menstruation irregular, FSH increased, and premature menopause, following human papillomavirus (HPV) vaccine from FDA Vaccine Adverse Event Reporting System (VAERS).

80) The Truth About HPV Vaccination, Part 3: Can It Prevent Cervical Cancer?

There are no valid studies showing the vaccine for the human papillomavirus, or HPV, prevents cervical cancer. However, there are studies suggesting the vaccine could increase the risk of cancer.
By The Epoch Times

81)  HPV vaccine study finds zero cases of cervical cancer among women vaccinated before age 14 By Annalisa Merelli Jan. 25, 2024

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82) Despite HPV Vaccine, Cervical Cancer Rates Keep Rising
Published on March 22, 2023 By Joseph Mercola 3/18/2023

In 2006, the first HPV vaccine, Gardasil, was licensed; Now, almost 17 years after the vaccine was introduced, there is a “troubling spike” in cervical cancer rates,[5] despite vaccination rates as high as 80 percent[6] (although rates vary widely between gender and ethnic groups.

As reported in the December 2022 issue of the International Journal of Gynecological Cancer:[8]  “When examining the trends over time, there has been an annual increase in distant stage cervical cancer at a rate of 1.3 percent per year. ..The largest increase is seen in cervical adenocarcinoma with an average annual percent change of 2.9 percent.”

when looking at HPV-related cancers in general, without regard for strain, rates have steadily increased since the vaccine’s introduction. As reported by the Kaiser Family Foundation (KFF) in July 2021,[11] “HPV-related cancers have increased significantly in the past 15 years[12] — in 2015, 43,000 people developed an HPV-related cancer compared to 30,000 in 1999.”

The data come from the Costa Rica HPV Vaccine Trial,[16] which involved more than 10,000 women aged 18-25 years. The HPV vaccine used in the trial was Cervarix, from GlaxoSmith Kline. It covers the two leading causes of cervical cancer, HPV 16 and 18, and provides partial protection against three other genotypes.
After a follow-up of 11 years, among vaccinated women, there was an excess of precancerous cervical lesions caused by genotypes not included in the vaccine, resulting in negative vaccine efficacy for those HPV variants

The results are likely the first evidence to date of ‘clinical unmasking’ with HPV vaccination, meaning that protection against the strains covered by the vaccine leaves women more prone to attack from other carcinogenic HPV variants.

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83) The HPV Vaccine: What You Need to Know About the Dumbest Vaccine Ever by Megan Heimer Published March 5, 2016 Opinion

The pre-licensure studies are laughable and I don’t even think we can call them “scientific,” which is both funny and sad at the same time. They lacked proper placebos, adequate controls, and literally no monitoring for long-term side-effects.
The safety and efficacy of Gardasil is nothing short of a joke….About how long does it take a 12-year-old girl before she realizes she’s infertile or has premature ovarian failure, and how many thousands of HPV vaccine reactions (including death) have to be reported before we wake up and smell the inevitable? The HPV vaccine is a disaster.

According to Merck—the maker of Gardasil, if a person has already been exposed to the HPV strains contained in the vaccine prior to injection, then Gardasil increases the risk of precancerous lesions by at least 44.6 percent.

This means we’re recommending a vaccine (that could cause very serious side-effects) against a sexually transmitted disease (that usually doesn’t) to ALL young girls and boys in this country based on global statistics, in order to prevent 4,000 U.S. deaths, which could be caused by a strain that isn’t even in the vaccine, something different entirely (as numerous things can cause cell abnormalities in the cervix), or the vaccine itself. Roughly, 30% of the population who actually get cervical cancer, gets it from an HPV strain that isn’t even in the vaccine. Hello? Anyone?

84) What You Need to Know About The HPV Vaccine  with Nathan Riley, MD, is a board-certified OB-GYN and fellow of ACOG . February 5, 2024 By Hilda Labrada Gore/ Weston Price

The risk of adverse effects from the HPV vaccine, quite frankly, according to Nathan, far exceeds the chances of getting cervical cancer.

Without asking, why do some people not develop cervical cancer? Most people don’t develop cervical cancer, even if they have HPV that hangs around for a while. HPV stands for Human PapillomaVirus. If you were to screen every single person, over 90% of people have been exposed to this but not over 90% are dying of cervical cancer.

Most people don’t develop cervical cancer, even if they have HPV that hangs around for a while.

Cervical cancer accounts for about 0.8% of all cancer deaths. We’re talking about a lifetime risk of probably 1 in 1 million.

the risk of a severe adverse reaction from the vaccine is higher than your risk of dying from cervical cancer.

85) Death and Disability from the HPV Vaccine 

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86)  Haruyama, Rei, Hiromi Obara, and Noriko Fujita. “Japan resumes active recommendations of HPV vaccine after 8· 5 years of suspension.” The Lancet Oncology 23.2 (2022): 197-198.

On Nov 26, 2021, the Ministry of Health, Labour, and Welfare of Japan officially issued an announcement to resume active recommendations of the human papillomavirus (HPV) vaccine, which had been suspended since June, 2013. (86)

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87) Can HPV Vaccine Prevent Cervical Cancer: Current Studies (Part 3)
By Yuhong Dong and Allison Krug 1/21/2023, Updated: 5/6/2023

In a large Swedish observational trial, which is treated as the most convincing study to prove the HPV vaccine’s effects on cervical cancer, a few confounding factors were not adequately balanced between the HPV vaccination group versus the unvaccinated group.

The National Cancer Institute’s Surveillance, Epidemiology, and End Results Program (SEER) data and another U.S. study found the HPV vaccine has no effects in reducing cancer rates.

Two other registry-based studies in Australia and the UK suggest that HPV vaccination is associated with increased cervical cancer rates in certain age groups.

88) HPV vaccine: the biggest medical fraud in history
updated on August 12, 2019  dr serge gregoire

Pap screening programs have reduced the incidence of cervical cancer dramatically to 7 in 100,000 in developed countries.

The biggest problem of the vaccine, however, is the dangerous side effects.

Between 1 June 2006 and 31 December 2008, 12,424 reports were submitted to the US Vaccine Adverse Events Reporting System (VAERS) regarding Gardasil™ after about 23 million doses total.

Serious adverse events included venous thromboembolism, 69 cases of Guillain-Barre syndrome (paralysis lasting for years, or permanently, sometimes eventually causing suffocation), autoimmune disorders, pancreatitis, anaphylaxis, transverse myelitis, and motor neuron disease.

70% of all HPV infections resolve without treatment within one year, and the number rises to well over 90% in two years.

Bottom line, the HPV vaccines do not work, they have never been shown to prevent cancer, they have never been tested properly, they contain a very high and dangerous amount of aluminum that no doctor wants to talk about.

89) The Troubling Truth Behind HPV Vaccines : Prepare to be Outraged  October 27, 2018 By Kendall Nelson

 

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https://academic.oup.com/jnci/advance-article-abstract/doi/10.1093/jnci/djad263/7577291

Palmer, Tim J., et al. “Invasive cervical cancer incidence following bivalent human papillomavirus vaccination: a population-based observational study of age at immunization, dose, and deprivation.” JNCI: Journal of the National Cancer Institute (2024): djad263.

Abstract Background

High-risk human papillomavirus causes cervical cancer. Vaccines have been developed that significantly reduce the incidence of preinvasive and invasive disease. This population-based observational study used linked screening, immunization, and cancer registry data from Scotland to assess the influence of age, number of doses, and deprivation on the incidence of invasive disease following administration of the bivalent vaccine.
Methods  Data for women born between January 1, 1988, and June 5, 1996, were extracted from the Scottish cervical cancer screening system in July 2020 and linked to cancer registry, immunization, and deprivation data. Incidence of invasive cervical cancer per 100 000 person-years and vaccine effectiveness were correlated with vaccination status, age at vaccination, and deprivation; Kaplan Meier curves were calculated.
Results   No cases of invasive cancer were recorded in women immunized at 12 or 13 years of age irrespective of the number of doses. Women vaccinated at 14 to 22 years of age and given 3 doses of the bivalent vaccine showed a significant reduction in incidence compared with all unvaccinated women (3.2/100 000 [95% confidence interval (CI) = 2.1 to 4.6] vs 8.4 [95% CI = 7.2 to 9.6]). Unadjusted incidence was significantly higher in women from most deprived (Scottish Index of Multiple Deprivation 1) than least deprived (Scottish Index of Multiple Deprivation 5) areas (10.1/100 000 [95% CI = 7.8 to 12.8] vs 3.9 [95% CI = 2.6 to 5.7]). Women from the most deprived areas showed a significant reduction in incidence following 3 doses of vaccine (13.1/100 000 [95% CI = 9.95 to 16.9] vs 2.29 [95% CI = 0.62 to 5.86]).
Conclusion

Our findings confirm that the bivalent vaccine prevents the development of invasive cervical cancer and that even 1 or 2 doses 1 month apart confer benefit if given at 12-13 years of age. At older ages, 3 doses are required for statistically significant vaccine effectiveness. Women from more deprived areas benefit more from vaccination than those from less deprived areas.

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Last updated on February 16th, 2024 by Jeffrey Dach MD